Results 81 to 90 of about 6,158,970 (292)

Developing and validating a holistic welfare assessment tool for zoo-housed great apes: Integrating resource-based measures with behavioural ecology insights.

PLoS ONE
Assessing the welfare of zoo-housed great apes is essential to ensure high standards of care, maintain zoos' ethical and educational credibility, and support their conservation roles.
Johanna Neufuss, Kirsten Pullen, Holly L Farmer, Cerian Tatchley, Nick Davis, Jackie Chappell, Susannah K S Thorpe   +6 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An analysis of language difficulties in Algebra I (Common core) assessments versus integrated Algebra assessments [PDF]

, 2016
1 online resource (iii, 67 pages) : illustrations.The purpose of this study was to determine if the difficult linguistic features of mathematics assessments correspond to teachers' perceptions of the assessments. A mixed methods research design was used
Spoth, Amy
core  

The concepts and development of a participatory regional integrated assessment tool. [PDF]

, 2008
This paper provides an overview of the development of the ‘Regional Impact Simulator’ – a user friendly software tool designed to allow stakeholders to perform integrated assessments of the effects of climate and/or socio-economic change on the ...
Cojacaru, G., Holman, Ian P., Rounsevell, M.D.A., Rounsevell, M. D. A., Nicholls, R. J., Pearn, K. R., Berry, P. M., Holman, I.P., Nicholls, R.J., Rounsevell, Mark, Pearn, Kerry R., Henriques, C., Harrison, P.A., Mokrech, M., Audsley, E., McLachlan, C., Holman, I. P., Fontaine, C., Richards, J.A., Harrison, P. A., Audsley, Eric, Richards, J. A., Pearn, K.R., Berry, P.M., Shackley, S., Shackley, Simon, Henriques, Catarina   +26 more
core   +1 more source

The impact of large-class flipped classrooms incorporating design thinking on self-awareness, team collaboration, learning efficiency, and comprehensive literacy of clinical medicine undergraduates

BMC Medical Education
Context Jining Medical University has adopted the traditional large-class teaching mode in its Histology and Embryology course. In this mode, students’ participation and learning outcomes are not satisfactory.
Hui Zhang, Xiaomei Wang, Xiaojin Li, Jinghua Zhai, Xiuguo Li, Yan Guo   +5 more
doaj   +1 more source

HOme-based Longitudinal Investigation of the multidiSciplinary Team Integrated Care (HOLISTIC): protocol of a prospective nationwide cohort study

BMC Geriatrics, 2020
Background The use of home health care (HHC) is increasing worldwide. This may have an impact not only on patients and their caregivers’ health but on care resource utilization and costs. We lack information on the impact of HHC on the broader dimensions
Jung-Yu Liao, Ping-Jen Chen, Yu-Lin Wu, Ching-Hsia Cheng, Sang-Ju Yu, Chi-Hsien Huang, Chia-Ming Li, Ying-Wei Wang, Kai-Ping Zhang, I-Te Liu, Hiroyuki Umegaki, Jun Hamano, Masanori Mori, Irene Petersen, Elizabeth L. Sampson, Chao A. Hsiung   +15 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Environmental Impact Assessment and Integrated Water Resources Management [PDF]

Global NEST Journal, 2013
Environmental Impact Assessment (EIA) plays an important role in the framework of the efforts aiming at the formulation of a complete water resources management. In our paper this issue is examined in an integrated way. The following issues are particularly examined : the notion of the EIA in general, the assessment methods and techniques on the ...
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source