Results 61 to 70 of about 14,546 (292)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Silicon-based photonic integration beyond the telecommunication wavelength range [PDF]

, 2014
In this paper we discuss silicon-based photonic integrated circuit technology for applications beyond the telecommunication wavelength range. Silicon-on-insulator and germanium-on-silicon passive waveguide circuits are described, as well as the ...
Malik, Aditya, Shimura, Y, Malik, A, Gassenq, Alban, Green, WMJ, Green, William M. J., Gencarelli, Federica, Healy, N, Roelkens, Roel, Uvin, Sarah, Tournie, E, Dave, Utsav Deepak, Shimura, Yosuke, Ryckeboer, Eva M.P., Peacock, Anna C., Osgood, Richard, Ryckeboer, Eva, Chen, Xia, Mashanovich, Goran, Z., Green, William W.M.J., Van Campenhout, Joris, Tournié, Eric, Leo, Francois, Loo, Roger, Nedeljkovic, M, Osgood, Richard M J R.M., Muneeb, Muhammad, Baets, Roel G. F., Van Campenhout, J, Gencarelli, F, Kuyken, Bart, Hu, Chen, Green, William M.J., Loo, R, Chen, X, Nedeljković, Miloš, Dave, Utsav, Hattasan, Nannicha, Cerutti, Laurent, Rodriguez, Jean-Baptiste, Mashanovich, Goran,, Sanchez, Dorian, Wang, Ruijun, Roelkens, Gunther, Baets, Roel, Rodriguez, Jean Baptiste, Healy, Noel, Shen, L, Vincent, Benjamin, Osgood, R, Healy, Noel V., Cerutti, L, Shen, Li, Mashanovich, Goran Z., Vincent, B, Liu, XP, Hens, Zeger, R'Ghif, Naima, Peacock, AC, Mashanovich, Goran, Rodriguez, JB, Mashanovich, G, Liu, Xiaoping   +62 more
core   +1 more source

Scalable integrated two-dimensional Fourier-transform spectrometry

Nature Communications
Integrated spectrometers offer the advantages of small sizes and high portability, enabling new applications in industrial development and scientific research.
Hongnan Xu, Yue Qin, Gaolei Hu, Hon Ki Tsang   +3 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

High-throughput speckle spectrometers based on multifractal scattering media [PDF]

Funding: S. A. Schulz and B. Kumar acknowledge funding from the EPSRC project EP/V029975/1: "Disorder enhanced on-chip spectrometers". L.D.N. acknowledges support from the National Science Foundation (ECCS-2015700, ECCS-2110204)".We present compact ...
Dal Negro, Luca, Schulz, Sebastian Andreas, Zhu, Yilin, Kumar, Bhupesh   +3 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Multi-mode interference waveguide chip-scale spectrometer (invited)

APL Photonics
Spectral analysis of light is one of the oldest and most versatile scientific methods and the basis of countless techniques and instruments. Miniaturized spectrometers have recently seen great advances, but challenges remain before they are widely ...
Md Nafiz Amin, Vahid Ganjalizadeh, Tyler J. Adams, Porter B. Dixon, Zoe Weber, Matthew DeMartino, Kevin Bundy, Aaron R. Hawkins, Holger Schmidt   +8 more
doaj   +1 more source

Compact and Flexible on-Chip Spectrometer Based on Metalens-Assisted Arrayed Waveguide Grating

IEEE Photonics Journal
To address the trade-off between footprint and spectral performance in on-chip spectrometers, this paper presents a compact and flexible on-chip metalens-assisted arrayed waveguide grating (AWG) spectrometer. By integrating an on-chip metalens within the
Xinyue Chen, Chenxi Wang, Hongliang Li, Wencheng Yue, Shuxiao Wang, Jian Shen, Xiangyu Gao, Wei Wang, Yan Cai   +8 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source