Results 101 to 110 of about 1,936,839 (295)

Efficient Online Transcription Factor Binding Site Adjustment by Integrating Transitive Graph Projection with MoRAine 2.0

Journal of Integrative Bioinformatics, 2010
We investigated the problem of imprecisely determined prokaryotic transcription factor (TF) binding sites (TFBSs). We found that the identification and reinvestigation of questionable binding motifs may result in improved models of these motifs ...
Wittkop Tobias, Rahmann Sven, Baumbach Jan   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A Novel High-Power-Factor Single-Switch Electronic Ballast for Compact Fluorescent Lamps

Eletrônica de Potência, 2004
In this paper a high-power-factor electronic ballast for compact fluorescent lamps based on the class E amplifier and featuring low voltage stress across the switch is presented.
Mario Ponce, Jaime E. Arau, Rene Osorio, Mario A. Juarez, J. Marcos Alonso   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Non-existence of limit cycles via inverse integrating factors

Electronic Journal of Differential Equations, 2011
It is known that if a planar differential systems has an inverse integrating factor, then all the limit cycles contained in the domain of definition of the inverse integrating factor are contained in the zero set of this function.
Leonardo Laura-Guarachi, Osvaldo Osuna, Gabriel Villasenor-Aguilar   +2 more
doaj  

Modeling Pavement Deterioration on Nepal’s National Highways: Integrating Rainfall Factor in a Hazard Analysis

Infrastructures
Pavement deterioration is influenced by various factors with degradation rates varying widely depending on the type of pavement, its use, and the environment in which it is located.
Manish Man Shakya, Kotaro Sasai, Felix Obunguta, Asnake Adraro Angelo, Kiyoyuki Kaito   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Precise Apple Quality Prediction Model Integrating Driving Factor Screening and BP Neural Network

Plants
Apple fruit quality is primarily determined by Vitamin C (VC), Soluble Saccharides (SSs), Titratable Acid (TA), and the Soluble Saccharides/Titratable Acid (SSs/TA).
Junkai Zeng, Mingyang Yu, Yan Chen, Xin Li, Jianping Bao, Xiaoqiu Pu   +5 more
doaj   +1 more source