Results 91 to 100 of about 8,918,506 (303)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Applying concepts of fuzzy cognitive mapping to model IT/IS investment evaluation factors [PDF]

open access: yes, 2002
The justification process is a major concern for many organisations that are considering the adoption of Information Technology (IT) and Information Systems (IS), and is a barrier to its implementation.
Sharif, AM   +3 more
core   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Integrating regional transportation and ecological factors into anaerobic digestion siting decisions

open access: yesnpj Sustainable Agriculture
Landfilling wasted food (WF) is a significant source of greenhouse gas emissions. Anaerobic digestion (AD) is emerging as a promising alternative to jointly manage WF and generate bio-based energy, yet its widespread adoption is limited by transportation
William R. Armington   +4 more
doaj   +1 more source

Factorization in integral domains

open access: yesJournal of Pure and Applied Algebra, 1990
Les AA. appellent ``atomique'' un anneau intègre R dans lequel tout élément est produit fini des éléments irréducibles. Sont étudiés les anneaux atomiques et les anneaux intègres avec la condition maximale pour les idéaux principaux, les anneaux atomique dans lesquels pour tout élément x non nul et non inversible il existe N(x) tel que pour toute ...
Anderson, D.D.   +2 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Integrating accompanying patients into clinical oncology teams: limiting and facilitating factors

open access: yesBMC Health Services Research
Objectives Since 2018, four establishments in Quebec have been instrumental in implementing the PAROLE-Onco program, which introduced accompanying patients (APs) into healthcare teams to improve cancer patients’ experience.
Marie-Pascale Pomey   +24 more
doaj   +1 more source

Predicting fire susceptibility: Integrating environmental factors with knowledge graph and neural network

open access: yesInternational Journal of Applied Earth Observations and Geoinformation
Global climate change and human activities have increased the frequency of wildfires, posing significant threats to ecosystems and human safety, including in regions traditionally less prone to wildfires.
Luanjie Chen   +2 more
doaj   +1 more source

Integrating regional and global security cooperation

open access: yes, 2002
Inhaltsverzeichnis: Klaus Lange, Leonid L. Fituni: Introduction (5-6); Victor I. Danilov-Danilyan, Valeri G. Draganov, et al.: Opening comments at the conference 'Integrating Regional and Global Security Cooperation', Moscow, 5-6 December 2000 (7-10). I.
Hanns-Seidel-Stiftung e.V. Akademie fuer Politik und Zeitgeschehen, Muenchen (Germany)   +2 more
core  

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