Results 101 to 110 of about 8,918,506 (303)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Integrating geospatial and environmental factors in colorectal cancer epidemiology: a regional study

Frontiers in Public Health
BackgroundColorectal cancer poses a major health challenge in Gansu Province, being one of the top causes of both incidence and mortality among gastrointestinal cancers.
Dongqiang He, Dongqiang He, Xueliang Li, Xueliang Li, Fan Liu, Fan Liu, Yalan Zhang, Yalan Zhang, Shengrui Yang, Shengrui Yang, Yang Zhao, Yang Zhao, Yang Zhao, Yang Zhao, Huijuan Cheng, Huijuan Cheng, Huijuan Cheng, Huijuan Cheng, Fan Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Jie Liu, Jie Liu, Jie Liu, Jie Liu, Yumin Li, Yumin Li, Yumin Li, Yumin Li   +29 more
doaj   +1 more source

Integrating extensive reading into the curriculum [PDF]

, 2017
departmental bulletin ...
Mayeda, Ann, MacKenzie, Dirk, 2616, 2615
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A typhoon-induced debris flow warning model integrating rainfall thresholds with geological factors

Frontiers in Earth Science
Typhoon-induced debris flows pose a significant threat to the southeastern coastal regions of China. The existing typhoon-induced debris flow warning models, however, are largely limited in the refinement of their rainfall thresholds and in their lack of
Yiming Wang, Yiming Wang, Dengcai Xu, Youjian Yang, Minglang Zhou, Wenqing Chen, Wei Lin   +6 more
doaj   +1 more source

INTEGRATING ECONOMY SYSTEMS OF RUSSIAN REGIONS INTO GLOBAL VALUE CHAINS: FACTORS AND CONDITIONS

Вестник Северо-Кавказского федерального университета, 2022
In the era of globalization the world economy could be characterized by the process of creating global value chains (GVC). Due to the participation in GVC national companies could get excess to the global export markets, high technologies and expertise ...
Marina Volkova, Yurii Yerygin
doaj  

Existence of integrating factors for higher-order ordinary differential equations

, 2007
We investigate the concept of integrating factors for higher-order ordinary differential equations introduced recently by one of the authors (NHI). The integrating factors for equations of order higher than one are determined by overdetermined systems ...
Ibragimov, Nail H., Khabirov, S.V.
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source