Results 91 to 100 of about 10,907,504 (376)

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Marcos do desenvolvimento infantil em crianças com necessidades de saúde especiais: relato de uma educação em saúde

Extensio: Revista Eletrônica de Extensão
Relatar a experiência de aplicar uma estratégia de educação em saúde sobre os marcos do desenvolvimento infantil, com acompanhantes de crianças com anomalias congênitas e hospitalizadas por longo período de tempo.
Maria Graciana da Silva Felipe, Leidiane Minervina Moraes de Sabino , Flávia Paula Magalhães Monteiro, Huana Carolina Candido Morais   +3 more
doaj   +1 more source

La cultura Embera y las políticas ambientales (Colombia): un análisis interdisciplinar desde la Biología y la Antropología

RELACult - Revista Latino-Americana de Estudos em Cultura e Sociedade, 2017
Hoy en día, el estudio académico fragmento al sujeto de estudio para analizarlo desde diferentes perspectivas, así el sujeto presenta variaciones desde los ojos profesionales que lo interpretan y describen.
Jair Hernando Castro, Edwin Alexander Sanabria   +1 more
doaj   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

A classifier-assisted evolutionary algorithm with knowledge transfer for expensive multitasking problems

Complex & Intelligent Systems
Surrogate-assisted evolutionary algorithms provide an effective means for complex and computationally expensive optimization problems. However, due to the scarcity of training samples, the prediction accuracy of frequently-used regression surrogate ...
Min Hu, Zhigang Ren, Zhirui Cao, Yifeng Guo, Haitao Sun, Hongyao Zhou, Yu Guo   +6 more
doaj   +1 more source

(Dis)connecting migration: transnationalism and nationalism beyond connectivity

Comparative Migration Studies, 2020
Transnationalism as a perspective that scrutinizes localities in more than one nation-state has helped to illuminate those aspects of lives of migrants that remain hidden when migration is seen through the lens of conventional migration theory.
Magdalena Nowicka
doaj   +1 more source

Two \u27Cop-Outs\u27 in Faith-Learning Integration: Incarnational Integration and Worldviewish Integration

, 1996
There are at least six different approaches to integration adopted by educationalists in recent years. These interconnect and may partially overlap. Two kinds of confusion in talk of integration are identified, along with four other substantive questions
Badley, Ken
core  

Integration of digital video sequences and supportive interactive animations into the Level 1 module Introductory Microbiology, to enhance the delivery and effectiveness of experimental microbiology. [PDF]

, 2004
Report of a CELT project on supporting students through innovation and researchFrom a previous innovations project during 2002/2003, the feasibility of producing and editing digital video of experimental microbiological procedures was established.
Protheroe, Roy, Sunderland, Duncan
core  

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source