Results 91 to 100 of about 1,601,500 (267)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Reliable Assessment of Healthcare Procedures: A Comparison of On-Site and Video-Based Methods
Advances in Medical Education and PracticeMinghui Yi,1 Yao Zhang,2 Fei Wu,1 Shilong Zhang,3 Menghui Hu,1 Changmei Liu,1 Bin Zheng,2 Jinling Yang1 1Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 2Surgical ...
Yi M +7 more
doaj
A driving feel oriented dynamic model for commercial vehicles
Scientific ReportsVirtual testing and evaluation of commercial vehicles require an accurate and comprehensive dynamic model to replace traditional driver-based field testing, thereby shortening the development cycle of commercial vehicles. However, existing dynamic models
Li Li +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Nature CommunicationsImage-guided surgery systems require precise fusion of fluorescence mapping and structural background imaging, yet current dual-camera system methods suffer from field-of-view misalignment and pixel offsets, risking millimeter-scale surgical errors.
Yujin Liu +12 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Water, Health, and Social Technologies: One Million Cisterns Programme Case Study
Annals of Global HealthBackground: This paper focuses on the impacts of climate change on vulnerable ecosystems and its implications for the health and well-being of populations.
José Firmino de Sousa Filho +21 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source