Results 181 to 190 of about 11,120,616 (283)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Mobilising global knowledge to strengthen the integration of community health workers (CHWs) in high-income countries with universal healthcare systems: a scoping review protocol. [PDF]

BMJ Open
Steenbeek A, Rothfus M, Doucette N, Shirin S, Indar A, Sarkar S, Khan F, Rani S.   +7 more
europepmc   +1 more source

Integrating EFL skills for authentically teaching specific grammar and vocabulary

, 2018
Julia Sevy-Biloon
openalex   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Clients' subjective experiences of navigating challenges in Gestalt therapy: an interpretative phenomenological analysis. [PDF]

Front Psychiatry
Kaisler RE, Schaffler Y.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Top three priorities for artificial intelligence integration into emergency, critical, and perioperative medicine: an interdisciplinary clinical expert consensus. [PDF]

J Anesth Analg Crit Care
Loriga B, Baglivo F, Bellini V, Adembri C, Montomoli J, Cascella M, Diedenhofen G, De Angelis L, Gentili N, Altini M, Pastori A, Gaggeri R, Bignami EG.   +12 more
europepmc   +1 more source

Integrative analysis of cancer imaging readouts by networks [PDF]

, 2014
Marco Dominietto, Nicholas F. Tsinoremas, Enrico Capobianco   +2 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Disentangling temporal integration and segregation in multiple object individuation. [PDF]

J Vis
Huang Y, Hao F, Li M, Zhong H, Ma Z, Fan Z, Ding X, Cheng X.   +7 more
europepmc   +1 more source