Results 41 to 50 of about 2,401,515 (298)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Large-scale optical switches by thermo-optic waveguide lens

PhotoniX
Optical switches are desired in telecom and datacom as an upgrade to electrical ones for lower power consumption and expenses while improving bandwidth and network transparency.
Tao Chen, Zhangqi Dang, Zeyu Deng, Shijie Ke, Zhenming Ding, Ziyang Zhang   +5 more
doaj   +1 more source

Quantification of upper limb position sense using an exoskeleton and a virtual reality display

Journal of NeuroEngineering and Rehabilitation, 2018
Background Proprioceptive sense plays a significant role in the generation and correction of skilled movements and, consequently, in most activities of daily living. We developed a new proprioception assessment protocol that enables the quantification of
Anne Deblock-Bellamy, Charles Sebiyo Batcho, Catherine Mercier, Andreanne K. Blanchette   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multi frequency multi bit amplitude modulation of spoof surface plasmon polaritons by schottky diode bridged interdigital SRRs

Scientific Reports, 2021
Multi-frequency multi-bit programmable amplitude modulation (AM) of spoof surface plasmon polaritons (SPPs) is realized at millimeter wave frequencies with interdigital split-ring resonators (SRRs) and In-Ga-Zn-O (IGZO) Schottky diodes.
Haotian Ling, Baoqing Zhang, Mingming Feng, Pengfei Qian, Yiming Wang, Qingpu Wang, Yifei Zhang, Aimin Song   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Marcos do desenvolvimento infantil em crianças com necessidades de saúde especiais: relato de uma educação em saúde

Extensio: Revista Eletrônica de Extensão
Relatar a experiência de aplicar uma estratégia de educação em saúde sobre os marcos do desenvolvimento infantil, com acompanhantes de crianças com anomalias congênitas e hospitalizadas por longo período de tempo.
Maria Graciana da Silva Felipe, Leidiane Minervina Moraes de Sabino , Flávia Paula Magalhães Monteiro, Huana Carolina Candido Morais   +3 more
doaj   +1 more source