Results 81 to 90 of about 538,303 (266)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Monitoring harmful algae blooms in Darlings Lake, New Brunswick, using K-means clustering of multi-spectral imagery

Frontiers in Remote Sensing
Darlings Lake, located in the Saint John River watershed, Canada, experienced lake-wide cyanobacteria blooms in the summers of 2021 and 2022. This study uses high spatial and temporal resolution satellite imagery from Planet Labs (Planet Labs, Inc., San ...
Catherine Evans, Romina Gehrmann, Christopher Greene, Sarah Blenis, Roxanne MacKinnon, Jason Newport, Sarah Vela, Matthew Smith, Zahra Sadeghi, Stan Matwin, Stan Matwin, Chris Whidden   +11 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

IMPLICATIONS OF THE ASSOCIATION AGREEMENT WITH THE EUROPEAN UNION ON THE FINANCIAL PUBLIC MANAGEMENT IN THE REPUBLIC OF MOLDOVA [PDF]

CES Working Papers, 2015
European integration is not just a goal of the foreign policy of the Republic of Moldova, but also a natural aspiration of an European nation to join the European family and the signing of the Association Agreement between Moldova and the European Union ...
Lilia ROTARU, Iulia CAPRIAN, Tatiana COVALSCHI   +2 more
doaj  

INTELLECTUAL PROPERTY AND GLOBAL INEQUALITY IN THE COVID-19 PANDEMIC

Sur: International Journal on Human Rights, 2021
The Covid-19 pandemic has increased the inequality of rights around the world. The intellectual property system contributes to this asymmetry by limiting access to vaccines and other health technologies to only a few producers.
Alan Rossi Silva, Clara Alves Silva, Felipe de Carvalho Borges da Fonseca, Pedro Villardi, Susana Rodrigues Cavalcanti van der Ploeg   +4 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Proposal for an Experimental Methodology for Evaluation of Natural Lighting Systems Applied in Buildings

Energies, 2017
This work has the objective of developing a methodology for the evaluation of indoor natural lighting systems, which, with speed and practicality, provides from real conditions of use a reliable result about the quality and performance of the proposed ...
Anderson Diogo Spacek, João Mota Neto, Luciano Dagostin Biléssimo, Oswaldo Hideo Ando Junior, Gustavo Pedro De Freitas Neto, Rodrigo Da Silva Giansella, Marcus Vinícius Ferreira De Santana, Celia De Fraga Malfatti   +7 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Professional agency as a psychological mechanism linking AI integration to language teacher identity

Frontiers in Psychology
IntroductionThe expanding use of classroom AI tools has made technology integration an increasingly identity-relevant aspect of teachers' work. Framed by psychological perspectives on professional identity, agency, and efficacy beliefs, this study ...
Shengju Zou, Shengju Zou, Caixia Zuo, Zhiyong Yang   +3 more
doaj   +1 more source