Results 61 to 70 of about 8,449,730 (256)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The Open Method of Coordination and integration theory: are there lessons to be learned? [PDF]
, 2009 This paper seeks to contextualize the Open Method of Coordination (OMC) and enrich our understanding of it by submitting constructivist insights to its policy assessment with a focus on the Employment Strategy (EES).
Tsarouhas, Dimitris
core
Optimization of Line Extraction Based on an Affine Camera Model
IEEE Access, 2019 Line feature constitutes important geometric structure information in image processing and is significant in visual navigation and 3-D structure contour extraction of 3-D objects.
Qiang Wang +5 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Zielonka's theory of the European Empire: A Challenge to Theory and Practice of European Integration
Australian and New Zealand Journal of European Studies, 2009 CESAA 16TH ANNUAL EUROPE ESSAY COMPETITION 2008 POSTGRADUATE CATEGORY The emergence of new theory to account for the sui generis phenomenon of European integration has produced a myriad of responses, challenging traditional approaches and creating new ...
Katrina Murray
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
(Re)theorising European Integration under Globalisation:A Political Economy Approach [PDF]
, 2004 In the last two decades, the European Union has become wider and deeper. In addition, the number of regional integration arrangements has increased dramatically since early 1990s. Against these developments, the focus of regional and European integration
Ugur, Mehmet.
core
Studia EuropejskieThe research problem addressed in this thesis concerns the definition of the international life of the European Union. After a review of the positions on defining the EU itself and a review of the related approaches, the authors turn to terms associated ...
Zbigniew Czachór, Piotr Baranowski
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Integration through activation?
Journal of Comparative Social Work, 2012 This paper addresses the question of how the activating welfare state carries out the paradoxical agenda of “help for self-help” in practice. Applying Niklas Luhmann’s concept of “inclusion” to local strategies of activating, i.e. “integrating” migrants
Tomoko Watarai
doaj +1 more source