Results 151 to 160 of about 6,800,285 (350)

Introducing integrative integrated migraine care (IIMC): A model and case presentation

, 2012
Introduction: Chronic migraine is one of the most common neurological disorders. Although different complementary therapies are available, few are integrated into standard patient care. Concept: The Department of Integrative Medicine at the University of
Cramer, H, Dobos, GJ, Rampp, T, Lauche, R, Paul, A   +4 more
core   +1 more source

Integrated medicine

BMJ, 2001
L, Rees, A, Weil
openaire   +3 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Standardization, Personalization and Real-world Practice in Pragmatic Trials for Integrative Medicine: The Methodological Design of a Semi-individualized Randomized Controlled Trial for Diabetic Kidney Disease

, 2020
Purpose: Pragmatic trials have been advocated across different specialties in the past few decades in a hope to generate real-world evidence to inform decisions in clinical practice.
Chan, KW, Tang, SCW
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Changes in chronically ill patients' self-management skills and resources following 14 days of inpatient treatment in a Department for Integrative Medicine: An observational pilot study

, 2013
Introduction: Integrative medicine inpatient treatment can improve health-related quality of life and mental health in chronically ill patients. This study aimed to explore the potential effect of a 14-day integrative inpatient treatment on chronically ...
Cramer, H, Esch, T, Langhorst, J, Wagner, K, Dobos, G, Lange, S, Lauche, R, Paul, A   +7 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Rosacea Fulminans Precipitated by Acute Stress: A Case Report Describing an Integrative Approach for a Patient Reluctant to Use Isotretinoin

, 2016
CONTEXT: Rosacea fulminans is a rare skin disorder with a multifactorial etiology. Stress is one of the common precipitating factors of this condition but is not often targeted in treatment.
Bednarek, Robert, Veerkamp, Patrick, Mousdicas, Nico   +2 more
core   +1 more source

Complementary and integrative medicine

Zdravniški Vestnik, 2011
: In 70’s and 80’s complementary and alternative medicines were mainly provided as an alternative to conventional health care. Many medical practitioners used to be against these disciplines.
Ante Zaloker, Urška Zaloker
doaj