Results 201 to 210 of about 196,514 (244)

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Saffold virus exploits integrin αvβ8 and sulfated glycosaminoglycans as cooperative attachment receptors for infection. [PDF]

Nat Commun
Okuwa T, Himeda T, Kobayashi K, Nomura N, Utani K, Koike S, Nakamura A, Higuchi M.   +7 more
europepmc   +1 more source

VE‐Cadherin–Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension‐Sensitive Intermediate State

Advanced Science, EarlyView.
This study investigates how endothelial monolayers balance cohesion and plasticity during mechanical stimulation. In HUVECs, shear stress induces a tension‐sensitive intermediate state in which junctional VE‐cadherin and actomyosin relaxation levels coordinate actin/integrin remodeling. This rapid, reversible state strengthens cell junctions, preserves
Jonas Franz, Maria Odenthal‐Schnittler, Jan Philip Kipcke, Jochen Seebach, Zahra Labbaf, Franziska Merten, Vesna Bojovic, Muna Taha, Johannes A. Eble, Erez Raz, Milos Galic, Hans Schnittler   +11 more
wiley   +1 more source

A novel epigenetic regulation of JAM-A by EZH2-DNMT3A cascade contributes to T cell adhesion via the activation of Rap1a in lupus patients. [PDF]

J Transl Autoimmun
Ding L, Gu H, Zhong Y, Chen H, Lin W, Lei Q, Yang L, Yu H, Song H, Zhang X, Yu M, Chang X, Lin J, Cui Q.   +13 more
europepmc   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

The ANGPTL3-integrin α5 axis drives retinal vascular leakage in diabetic retinopathy. [PDF]

J Transl Med
Ke J, Xu Y, Zhu Y, Feng X, Cao H, Yang L, Zhao D.   +6 more
europepmc   +1 more source

Integrin β1 in osteoblast differentiation and migration during acute bone loss after fracture: Regulation of extracellular signal-regulated kinase 1/2 signaling pathway. [PDF]

Cytojournal
Luan J, Li J, Wang J.
europepmc   +1 more source

Association of tissue lymphocyte immunophenotype and clinical outcomes: A prospective study in patients with ulcerative colitis treated with vedolizumab. [PDF]

PLoS One
Ando K, Kashima S, Sakatani A, Konishi H, Maemoto A, Ito T, Taruishi M, Hamagami K, Ishiguro K, Fujiya M.   +9 more
europepmc   +1 more source

Decoding collagen cues: the interplay of integrins and discoidin domain receptors in health and disease. [PDF]

J Biomed Sci
Trono P, Masi I, Ottavi F, Rosanò L.
europepmc   +1 more source