Results 241 to 250 of about 317,716 (343)

Thrombospondin-4 drives lymphangiogenesis through cooperation with VEGF-C in human bladder cancer. [PDF]

Int J Med Sci
Hwang TI, Peng PW, Chi MS, Chou KY, Tsai TF, Ho CY, Chang AC.   +6 more
europepmc   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

ITGA2B/ITGB3-Related Macrothrombocytopenia Associated With Gain-of-Function Mutations in ITGA2B or ITGB3 Genes. [PDF]

J Cell Mol Med
Wu J, Yan H, Li Z, Zhu Y, Shao R, Xin H, Jia T, Ge M, Zhang L, Jiang S, Mao J, Huang J, Fang C, Xi X, Shi X.   +14 more
europepmc   +1 more source

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

Nature, 2014
M. Paszek, Christopher C DuFort, O. Rossier, Russell Bainer, J. Mouw, K. Godula, J. Hudak, J. Lakins, Amanda C. Wijekoon, L. Cassereau, Matthew G. Rubashkin, M. Magbanua, K. Thorn, M. Davidson, H. Rugo, John W. Park, D. Hammer, Grégory Giannone, C. Bertozzi, V. Weaver   +19 more
semanticscholar   +1 more source

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Advanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi   +5 more
wiley   +1 more source

The role of suPAR and related proteins in kidney, heart diseases, and diabetes. [PDF]

J Clin Invest
Reiser J, Hayek SS, Sever S.
europepmc   +1 more source

An Opto‐Actuated Hydrogel for Cell Mechanoactuation and Real‐Time Force Monitoring

Advanced Science, EarlyView.
Researchers developed a mechanoactuated hydrogel interface where nanomachines exert forces on adhesion receptors and allow monitoring of traction force responses in real time. They demonstrate reversible talin recruitment, enhanced F‐actin polymerization, and a reduction in cell traction force when force is locally applied to focal adhesions of ...
Rinku Kumar, Marc A. Fernandez‐Yague, Adrien Bessaguet, Hosoowi Lee, Nicolas Giuseppone, Andrés J. García, Aránzazu del Campo   +6 more
wiley   +1 more source

CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge. [PDF]

J Cell Sci
Whitelaw JA, Ghosh S, Lilla S, Nikolaou S, Tweedy L, Fort L, Paul NR, Zanivan S, Gadegaard N, Insall RH, Machesky LM.   +10 more
europepmc   +1 more source

Metabolic control of cell adhesion and migration through beta1A integrin acetylation : be aware of the acetylation switch!

, 2015
Birgit Kastberger
openalex   +2 more sources

ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth

Advanced Science, EarlyView.
This study identifies truncated ITM2B as a regulator of migrasome formation in renal cell carcinoma (RCC) cells. The ITM2B truncation not only facilitates migrasome formation by recruiting TSPAN4, but also sorts active caspase‐7 into migrasomes. The internalization of active caspase‐7‐enriched migrasomes by macrophages stimulates IL‐6 secretion to ...
Qi‐tao Chen, Qiao‐ling Huang, Ming‐zhi Han, Xue‐hui Hong, De‐yi Feng, Lu‐ming Yao, Wen‐bin Hong, Yue Chen, Ya‐ying Huang, Hang‐zi Chen, Qiao Wu   +10 more
wiley   +1 more source