Results 11 to 20 of about 1,443,144 (267)
TO INTEGRATE OR NOT TO INTEGRATE [PDF]
BMJ Supportive & Palliative Care, 2014 The Development of an Integrated Community Advance Care Planning Service across neighbouring Boroughs and its impact on the uptake of End of Life Care Tools.BackgroundThe first Advance Care Facilitator was introduced in Knowsley in December 2008; the overall purpose of the post was to make quality improvements in the provision of End of Life Care by ...
Janet Cummins +2 more
openaire +1 more source
ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
Nature Communications, 2020 Recombination requires DNA break formation by SPO11, following which SPO11 is thought to be released. Here, the authors show that meiotic hotspots retain SPO11 through a recombination intermediate dependent on the methyltransferase PRDM9, and that the ...
Jacob Paiano +10 more
doaj +1 more source
Good practice in medicine and biology: scientific integrity needs global bioethics
Journal of Translational Medicine, 2023 We consider scientific integrity to constitute a new theory of morality of science, in a very specific deontological sense. Indeed, at least in practice, scientific integrity extends beyond scientific concerns, seeking to develop specific moral duties ...
Henri-Corto Stoeklé +2 more
doaj +1 more source
Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes
Nature Communications, 2019 Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). Here authors use biochemical and single molecule measurements to show that ATAD5-RLC has the most potent PCNA ...
Mi-Sun Kang +13 more
doaj +1 more source
Energies, 2022 The processes of HTHP well fracturing, oil drive, and gas recovery are accompanied by the non-stationary flow of medium in the tubing, which may lead to periodic vibration and cause the failure and fatigue of the tubing, thread leakage, and bending ...
Lu Cui +4 more
doaj +1 more source
Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells
Frontiers in Oncology, 2023 The limitations of current cancer therapies, including the increasing prevalence of multidrug resistance, underscore the urgency for more effective treatments. One promising avenue lies in the repurposing of existing drugs.
Syrina Fred Mehrabi +3 more
doaj +1 more source
Cells, 2022 Thyroid hormone receptor-interacting protein 13 (TRIP13) participates in various regulatory steps related to the cell cycle, such as the mitotic spindle assembly checkpoint and meiotic recombination, possibly by interacting with members of the HORMA ...
Hyeongsun Jeong +15 more
doaj +1 more source
Surface modification of flat cable conductors: a path to withstand the aggressive space environment
Mechanics and Advanced Technologies, 2020 A novel ion-beam surface treatment process with simultaneous surface renewal (IB/SSR) providing charge-dissipative properties to the treated surfaces was developed at ITL and successfully used for treatment of both sides of variously shaped and sized ...
Jacob Kleiman, Zelina Iskanderova
doaj +1 more source
ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
Nature Communications, 2019 How the replisome machinery contributes to fork stability under replication stress is currently not clear. Here the authors reveal a role for ATAD5 in maintaining genome integrity during replication stress by promoting replication restart through RAD51 ...
Su Hyung Park +14 more
doaj +1 more source
Proteomic discovery of DEK and NUMA1 as new players in UV-induced DNA damage repair mechanisms
Cell Death DiscoveryUltraviolet (UV)-induced DNA lesions threaten genomic stability and are associated with skin carcinogenesis. These lesions are primarily repaired by the nucleotide excision repair (NER) pathway.
Namwoo Kim +7 more
doaj +1 more source