Results 41 to 50 of about 2,112,951 (292)

Sepsis-2.5: Resolving Conflicts Between Payers and Providers

Critical Care Explorations, 2023
Competing definitions of sepsis have significant clinical implications and impact both medical coding and hospital payment. Although clinicians may prefer Sepsis-2, payer use of Sepsis-3 to validate clinical diagnoses may result in denial of payment or ...
Howard Rodenberg, MD, MPH, Theodore Glasser, MD, Alison Bartfield, MD, Shalika Katugaha, MD   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Structural and Computational Analysis of Pseudomonas aeruginosa DNA Gyrase Reveals Molecular Characteristics That May Contribute to Ciprofloxacin Resistance

Biomolecules
Pseudomonas aeruginosa is considered a priority pathogen by the World Health Organization due to its resistance to antibiotics. Isolates resistant to ciprofloxacin (CPFX), a bactericide commonly used against P.
Lalith Perera, Libertad García-Villada, Andrea M. Kaminski, Natalya Degtyareva, Lars C. Pedersen, Paul W. Doetsch   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Learning with Integrity: The Global Integrity Learning Journey [PDF]

, 2023
For nearly 20 years, Global Integrity has contributed to anti-corruption efforts that improve public service delivery outcomes by producing cutting-edge research, strengthening local responses, and building an extensive global network of governance ...

core   +2 more sources

Integrity of Integrated Navigation Systems [PDF]

2018 IEEE Conference on Communications and Network Security (CNS), 2018
Computerized systems are revolutionizing modern ships’ bridges and maritime operations. Central components in this are Integrated Navigation Systems (INS) and Electronic Chart Display and Information Systems (ECDIS) which provide the maritime navigator with the ship’s position and displays it in electronic charts.
Lund, Mass Soldal, Gulland, Jørgen Emil, Hareide, Odd Sveinung, Jøsok, Øyvind, Weum, Karl Olav Carlsson   +4 more
openaire   +5 more sources

Safeguarding integrity: a guide to the integrity system in Victoria [PDF]

, 2014
The Safeguarding Integrity Guide aims to help public sector employees and the broader community understand Victoria\u27s integrity system and its key agencies.

core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Surface Modification Technologies for Space and Planetary Applications

Mechanics and Advanced Technologies
This paper presents an overview of processes developed in our company for applications in various space and planetary environments. A number of materials including polymers, paints and other organic-based materials undergo dramatic changes and ...
Якоб Клеймен
doaj   +1 more source