Results 41 to 50 of about 118,069 (266)
Applied Sciences, 2023 The prime objective of the cloud data storage process is to make the service, irrespective of being infinitely extensible, a more reliable storage and low-cost model that also encourages different data storage types. Owing to the storage process, it must
Adnan Tahir +7 more
doaj +1 more source
View Constraints: an Interpretation of Integrity Constraints for Security [PDF]
, 1997 Security is seen as fondamental to S.W.I.F.T.'s business, second only to network availability. The security infrastructure in terms of organisation, direction, processes and tools, must be appropriate. The world as we know it is changing rapidly as technology marches forward and as the modern business world expands to take advantage of the new ...
openaire +3 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Deriving Triggers from Integrity Constraint Specifications in the Database Management Systems
Acta Polytechnica, 2001 Supporting integrity constraints is essential for database systems. Integrity constraints are used to ensure that the data in a database complies with rules that have been set to establish accurate and acceptable information for a database.
M. Badawy, K. Richta
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
STUDY ON THE MATCHING OF CRACK-TIP CONSTRAINTS AMONG DIFFERENT LABORATORY SPECIMENS
Jixie qiangdu, 2019 The matching of crack tip constraints is a difficult problem in the current structure integrity assessment method.Due to the restriction of current constraint parameters,the matching of crack tip constraints between different laboratory specimens,between
YANG Jie, LIU YuMan, WU Fan
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source