Results 41 to 50 of about 350,094 (311)
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi +5 more
wiley +1 more source
Identification of influent factors on surface integrity in nickel-base superalloy drilling [PDF]
For the critical rotating components in aeronautical industry, the metallurgical quality achieved after machining conditions could determine their mechanical behaviour in fatigue. To guarantee this quality, the tools, materials and cutting conditions are
Dutilh, Vincent +4 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Peaks Over Threshold Method for Structural Health Monitoring Detector Design [PDF]
Structural Health Monitoring (SHM) system offers new approaches to interrogate the integrity of structures. The most critical step of such systems is the damage detection step since it is the first and because performances of the following steps (damage ...
NAZIH MECHBAL +5 more
core +1 more source
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
GNSS integrity is an essential component for ensuring the reliability of safety-critical applications using Global Navigation Satellite Systems (GNSSs).
Yuting Gao +4 more
doaj +1 more source
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Integrity Monitoring for Bluetooth Low Energy Beacons RSSI Based Indoor Positioning
Indoor wireless positioning using Bluetooth Low Energy (BLE) beacons have attracted considerable attention from industry and academia given the many advantages of this technology such as low power consumption, low cost, easy layout, high availability ...
Haiyun Yao +4 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
A New Real-Time File Integrity Monitoring System for Windows-based Environments [PDF]
The ability to get real-time notifications about unexpected changes in files or directory structure occurred by unauthorized accesses is a necessity in the defense from hackers.
Zlatkovski, Dragi +3 more
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