Results 121 to 130 of about 7,192,626 (242)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

SYSTEM ARCHITECTURE-BASED DESIGN METHODOLOGY FOR MONITORING THE GROUND-BASED AUGMENTATION SYSTEM: CATEGORY I – INTEGRITY RISK DOI 10.5028/jatm.2012.04025611

Journal of Aerospace Technology and Management, 2012
This paper has described a method to accomplish the Ground-Based Augmentation System signal-in-space integrity risk monitoring for a ground station specified by ICAO, Annex 10, Vol.1 and RTCA DO-245-A, wich is a mandatory requirement to meet the ...
Paulo Elias, Osamu Saotome
doaj  

The integrity of the corticospinal tract and corpus callosum, and the risk of ALS: univariable and multivariable Mendelian randomization

Scientific Reports
Studies suggest that amyotrophic lateral sclerosis (ALS) compromises the integrity of white matter fiber tracts, primarily affecting motor fibers. However, it remains uncertain whether the integrity of these fibers influences the risk of ALS.
Jieying Wu, Gan Zhang, Linjing Zhang, Shan Ye, Tao Huang, Dongsheng Fan   +5 more
doaj   +1 more source

Well Integrity Risk Assessment - Software Model for the Future

, 2018
Risk is a topic reaching over many layers in an organization and its structure. From operator and asset level to individual wells and operations. The oil and gas industry's joint consensus of primary focus is safe and effective production.
Sigbjorn Sangesland, Bjorn Brechan, Stein Inge Dale   +2 more
core   +1 more source

Design and evaluation of FEBS Education and Training Academy module – Integrating generative artificial intelligence into life‐science education

FEBS Open Bio, EarlyView.
Life‐science educators from 14 countries redesigned their own course materials with generative AI in a three‐session, pedagogy‐first FEBS Education and Training Academy workshop built on PICRAT. Among 12 matched respondents, four more reported high confidence in each of five practical domains, and 10 of 13 reported implementing at least one idea ...
Zvonimir Mlinarić, Ali Burak Özkaya
wiley   +1 more source

CCUS wellbore integrity risk assessment and management based on game theory combination weighting-DHHFLOWLAD

Petroleum
In response to the increasing risk of well integrity failure during carbon dioxide capture, utilization and storage (CCUS), a multi-index evaluation and recommendation model based on the game theory combination-authority-DHHFLOWLAD was proposed to ...
Bing Qin, Wenjing Duan, Suhong Nan, Bing Liang, Zhanshan Shi, Jianfeng Hao   +5 more
doaj   +1 more source

GBS‐MeDIP: A method for the simultaneous identification of genetic and epigenetic variants in tumors

FEBS Open Bio, EarlyView.
GBS‐MeDIP combines DNA sequencing with enrichment of methylated DNA to profile genetic and epigenetic variation in the same reduced genomic fraction. Applied to gastric cancer and parathyroid tumors, it identifies sequence variants, copy number changes, and differentially methylated regions together, helping distinguish true epigenetic changes from ...
Fábio Pértille, Shiva Rezaei, Julia Uffenorde, Oliver Gimm, Mohammad Ali Hosseinpour Feizi, Luiz Lehmann Coutinho, Carlos Guerrero‐Bosagna   +6 more
wiley   +1 more source

Science and Communication as the Foundation of Food Safety

Journal of Food Protection
: The reliability of scientific information and the appropriateness of its communication across stakeholders are essential for effective food control systems.
Carmen Diaz-Amigo, Leticia Bartolomé del Pino, Vittorio Fattori, Catherine Bessy   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source