Results 71 to 80 of about 7,192,626 (242)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Risk-based asset integrity indicators

, 2012
Asset integrity is a major concern of process facilities. Monitoring and assessing asset integrity is a challenging task due to the involvement of various dependent and independent parameters. Monitoring and assessing asset performance through indicators
Faisal Khan (14741095), Hassan, J (15574244)   +1 more
core  

Secure agent data integrity shield [PDF]

, 2004
In the rapidly expanding field of E-Commerce, mobile agent is the emerging technology that addresses the requirement of intelligent filtering/processing of information. This paper will address the area of mobile agent data integrity protection.
Yang, Y., Guan, SU, Yang, Y, Guan, S.-U.
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Dynamic risk assessment framework for offshore pipelines corrosion under insulation

Journal of Pipeline Science and Engineering
Corrosion under insulation (CUI) remains a critical threat to the integrity and reliability of offshore and marine pipeline systems due to its hidden nature, complex degradation mechanisms, and limited inspection strategies. This study presents a dynamic,
Momohjimoh Ajari Yakubu, Susan Caines, Faisal Khan, Sidum Adumene   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Analytical model of the ADS-B information integrity radar monitoring

Научный вестник МГТУ ГА, 2016
The paper presents a probable solution of enhancing the ADS-B information integrity level using reference data from a secondary surveillance radar.
V. L. Kuznetsov, V. V. Dupikov
doaj  

Data-driven model to predict burst pressure in the presence of interacting corrosion pits

Journal of Pipeline Science and Engineering
This paper presents a data-driven approach to predict the pipelines’ corrosion-induced Burst failure. In this approach, different aspects of pit growth progression and spatial distribution of pits are simulated.
Rioshar Yarveisy, Faisal Khan, Rouzbeh Abbassi   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source