Results 71 to 80 of about 704,328 (301)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Dynamic risk assessment framework for offshore pipelines corrosion under insulation
Journal of Pipeline Science and EngineeringCorrosion under insulation (CUI) remains a critical threat to the integrity and reliability of offshore and marine pipeline systems due to its hidden nature, complex degradation mechanisms, and limited inspection strategies. This study presents a dynamic,
Momohjimoh Ajari Yakubu +3 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Data-driven model to predict burst pressure in the presence of interacting corrosion pits
Journal of Pipeline Science and EngineeringThis paper presents a data-driven approach to predict the pipelines’ corrosion-induced Burst failure. In this approach, different aspects of pit growth progression and spatial distribution of pits are simulated.
Rioshar Yarveisy +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Analytical model of the ADS-B information integrity radar monitoring
Научный вестник МГТУ ГА, 2016 The paper presents a probable solution of enhancing the ADS-B information integrity level using reference data from a secondary surveillance radar.
V. L. Kuznetsov, V. V. Dupikov
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Assessing Well Integrity Risk: A Qualitative Model
, 2011 For successful delivery of Well Integrity, there needs to be an understanding of the risks that can cause undesirable events such as safety hazards or loss of containment.
B.. Chastain, J. C. Dethlefs
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Well Integrity Risk Assessment - Software Model for the Future
, 2018 Risk is a topic reaching over many layers in an organization and its structure. From operator and asset level to individual wells and operations. The oil and gas industry's joint consensus of primary focus is safe and effective production.
Sigbjorn Sangesland +2 more
core +1 more source