Results 31 to 40 of about 280,922 (258)

L’adossement réflexif à la recherche comme activité heuristique, praxéologique, critique

open access: yesQuestions Vives, 2020
This article is based on a methodological position, that of the “thick” intersection of the three concepts of heuristicity, praxeology and criticism, from a more empirical than theoretical perspective.
Nicolas Sembel
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

On the Question About Modeling the Process of Managing the Intellectual Activity

open access: yesУправленческие науки, 2016
Innovative activity of any business entity prefers a reliable and effective intellectual management system. Proper design of the system, its substantive content and effective use in the process of elaboration, adoption and implementation of management ...
V. M. Zotov
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Diagnosis of Parkinson’s Disease Type 1 and 2 on the Electrical Activity of Hand Muscle During Isometric Contraction With and Without Intellectual Activity

open access: yesInternational Clinical Neuroscience Journal, 2020
Background: Parkinson’s disease (PD) is the third most common neurodegenerative disease in the central nervous system. It is a degenerative and slowly progressive disease.
Roya Sotoodeh   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Major Damage as the Element of Objective Part of Corpus Delicti Provided for by Article 180 of the Criminal Code of the Russian Federation

open access: yesVestnik Omskoj Ûridičeskoj Akademii, 2015
The article considers different approaches to the understanding of objective element of crime provided for by article 180 of the Criminal Code of the Russian Federation (illegal use of trademark) as well as the issues of law enforcement of the norm under
Zhaivoronok A. V., Timko S. A.
doaj   +2 more sources

تصميم ألعاب تعليمية قائمة على التكامل المعرفي من خلال التربية الفنية لدى طلاب مرحلة التعليم الأساسي [PDF]

open access: yesمجلة التربية النوعية والتكنولوجيا, 2017
إن العديد من القضايا المعاصرة التي تواجه المجتمع الإنساني في القرن الحادي والعشرين تتطلب منهجا تفاعليا في البحث والتعليم والتفكير لكى تحقق نتائج إيجابية مقبولة ، وتعتبر الألعاب التعليمية من الأساليب الحديثة في التدريس ، والتي تعد من أهم الأساليب ...
إيناس حسنى أحمد يونس
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

THE INTELLECTUAL POTENTIAL ECONOMIC ESSENCE AS AN OBJECT OF THE ENTERPRISE’S INNOVATIVE ACTIVITY MANAGEMENT

open access: yesСоціальна економіка, 2023
The article examines the intellectual potential economic essence as an object of the enterprise’s innovative management in the of the knowledge-based economy formation.
Halyna Ostrovska
doaj   +1 more source

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