Results 51 to 60 of about 280,922 (258)

MODEL OF COGNITIVE ACTIVITY OF THE LEARNER ON INTERACTION WITH THE NEW INFORMATION REALITY [PDF]

Krymskij Naučnyj Vestnik, 2015
The article discusses the relevance and the way to change the traditional model of cognitive activity aimed at human interaction (learner) with modern information-technology-saturated world.
Galina Vodyanenko
doaj  

Truth-Telling and Intellectual Activism [PDF]

Contexts, 2013
Patricia Hill Collins, a feminist public intellectual, discusses the importance of speaking across multiple audiences.
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Modeling the Collective Intelligence of Innovatively Integrated Enterprises

Journal of Vasyl Stefanyk Precarpathian National University
The article addresses the challenges of modelling the collective intelligence of innovation-integrated enterprises in the context of digital transformation. An overview of mathematical models used to describe collective intelligence technologies is given.
Halyna Ostrovska, Borys Shelestovskyi
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

INSTITUTIONAL REGULATION OF USING AI-BASED SERVICES THROUGH THE KANO MODEL: THE CASE OF KHERSON STATE UNIVERSITY

Інформаційні технології і засоби навчання
The rapid advancement of artificial intelligence technologies has fundamentally transformed higher education, encouraging universities to develop comprehensive institutional policies for AI implementation across academic and administrative processes ...
Oleksandr Spivakovsky , Serhii Omelchuk, Vitaliy Kobets , Maksym Poltoratskyi, Daria Malchykova, Oleksandr Lemeshchuk   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Psycho technology of personality reserves activation when teaching foreign language. Practical experience

Консультативная психология и психотерапия, 2016
The article considers the problems of the role of implicit memory in education. The Activation Method (also known as Professor G.A. Kitaygorodskaya Method) is analyzed from the point of view of the implicit memory.
Savinkina N.B.
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source