Results 71 to 80 of about 280,922 (258)

Intellect and intellectual activity

open access: yes, 2009
The article deals with the influence that social relations exercise on the development of the individual's intellectual capacity.  
openaire   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

Russia’s inventive activity in new technological trends

open access: yesВестник университета
The study is devoted to analyzing peculiarities of inventive activity development in Russia in the conditions of sanctions restrictions and a new technological mode formation.
V. V. Narbut
doaj   +1 more source

Physical Activity in People with Intellectual Disability: A Narrative Review

open access: yesمجله پژوهش در علوم توانبخشی, 2019
Introduction: The levels of physical activity and exercise are two important factors to improve health in people with intellectual disability. Several studies addressed the level of physical activity, and the benefits, cautions, and principles of ...
Javid Mostamand, Hamzeh Baharlouei
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

AN ONTOLOGY OF INTELLECTUAL ACTIVITY TASKS

open access: yesOntology of designing, 2015
An overview of publications presenting classifications of tasks solved by intellectual systems, descriptions of these tasks and formal specifications of these tasks are given. Actuality of the classification based on general principles and terminology well-determined by mathematical apparatus is shown.
Kleschev А., Shalfeeva Е.
openaire   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

INTELLECTUAL PROPERTY: CATEGORIAL DEVICE AND INSTITIONAL DEVELOPMENT

open access: yesМир новой экономики, 2018
The author of article raises the questions of terminology of the sphere of intellectual activity that is especially actual in the conditions of economy of knowledge.
ANZHELIKA PETROVNA Buevich
doaj  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

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