Results 221 to 230 of about 2,601,816 (350)

Clinical trial barriers in neurostimulation for pediatric drug‐resistant epilepsy

Epileptic Disorders, EarlyView.
Abstract Objective The NeuroPace responsive neurostimulation (RNS) System effectively treats focal drug‐resistant epilepsy (DRE) in adults but lacks pediatric regulatory approval. Despite effective off‐label pediatric use, systemic device‐trial challenges have impeded label expansion.
Mira C. Hasner, Faith C. Robertson, Nathaniel D. Sisterson, Gabriel Lazaro‐Munoz, Florence T. Bourgeois, James W. Wheless, Steven M. Wolf, Peter C. Warnke, Saadi Ghatan, Joffre Olaya, Catherine J. Chu, Brian N. Lundstrom, Sanjeev V. Kothare, Marytery Fajardo, Marike L. D. Broekman, R. Mark Richardson   +15 more
wiley   +1 more source

[X-linked intellectual disability syndrome with macrocephaly due to BRWD3 gene deletion]. [PDF]

Rev Neurol
Arroyo-Carrera I, Romero-Peguero R, Martín-Fernández R, Ramajo-Polo A, García-Navas Núñez V.   +4 more
europepmc   +1 more source

Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome. [PDF]

Nat Commun, 2020
Cooper A, Butto T, Hammer N, Jagannath S, Fend-Guella DL, Akhtar J, Radyushkin K, Lesage F, Winter J, Strand S, Roeper J, Zechner U, Schweiger S.   +12 more
europepmc   +1 more source

Heart Transplant for Noncompaction Cardiomyopathy in NONO ‐Related Syndromic Intellectual Disability

Julia S. Singer, Dorota Garczarczyk‐Asim, Miriam Michel, Thomas Müller, Lukas Hackl, Andreas Janecke   +5 more
openalex   +1 more source

Postoperative outcomes and predictors of functional sequelae following hemispheric surgery in Rasmussen's encephalitis: A retrospective cohort study from the global pediatric epilepsy surgery registry

Epileptic Disorders, EarlyView.
Abstract Objective Rasmussen's encephalitis (RE) is a rare and progressive, immune‐mediated epileptic encephalopathy characterized by drug‐resistant seizures and neurological decline. While hemispheric disconnection (HD) is the gold standard treatment for effective seizure control, this procedure carries significant risk of permanent neurological ...
Krish Nair, Nicholas Benjamin, Emily Harford, Levi Shelton, Ariel Heller, Katherine Cobb‐Pitstick, Luis Fernandez, Ross Carson, Monika Jones, William Welch, Taylor J. Abel, Ruba Al‐Ramadhani   +11 more
wiley   +1 more source

Risk of hostility and aggression with perampanel monotherapy versus combination therapy in pediatric epilepsy: A Japanese post‐marketing database study using a nested case–control design

Epileptic Disorders, EarlyView.
Abstract Objective To compare the incidence of hostility‐ and aggression‐related adverse events in children with focal‐onset seizures (FOS), with or without focal to bilateral tonic–clonic seizures (FBTCS), receiving perampanel as monotherapy or in combination with other antiseizure medications (ASMs).
Yukitoshi Takahashi, Masato Takeuchi, Akiko Yoshimura, Kasumi Daidoji, Kazuhiro Matsutani, Mika Ishii   +5 more
wiley   +1 more source

Decoding ZMYND11-Related Syndromic Intellectual Disability: From Epigenetic Mysteries to Therapeutic Horizons

Rui Zheng, Zi-Qin Liu, Ying Shen, Xin‐Tai Wang   +3 more
openalex   +2 more sources

Lipodystrophy-intellectual disability-deafness syndrome [PDF]

, 2020
openaire   +1 more source

Symptomatic hyperprolactinemia mimicking pituitary pathology in a child with Landau–Kleffner syndrome, autism spectrum disorder, and intellectual disability: a case report

Swetang J Shah, Viral Goradia, Aahna V. Dattani, Sireesha Palkamsetti, Usha Ravi, Anshuman Srivastava   +5 more
openalex   +1 more source

Microphthalmia-ankyloblepharon-intellectual disability syndrome [PDF]

, 2020
openaire   +1 more source