Results 61 to 70 of about 9,284,085 (237)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Approaches to the History of Philosophical Concepts

História da Historiografia
This article addresses historiographical questions about the concepts by which philosophy attempts to provide answers to the problems it poses. It argues for a view of philosophy as a historically dynamic intellectual practice that has no clear and ...
Silvia Manzo
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Approach to Intellectual History and the Intellectual Subject

Journal of Social Sciences: Transformations & Transitions, 2022
Intellectual history has been approached in different ways by different schools of thought, in terms of its conception and methodological treatment. We can mention, among the main ones, the French School, and the Cambridge School; as well as the Begriffsgeschichte or history of concepts.
openaire   +1 more source

History of Intellectual Culture : International Yearbook of Knowledge and Society

The latest issue of History of Intellectual Culture (HIC) explores experimental spaces for knowledge production in the long nineteenth century, moving beyond traditional academic institutions. Articles delve into intentional communities, colonial gardens,
Roesch, Claudia, Kwaschik, Anne,, Kwaschik, Anne, Roesch, Claudia,, Lerg, Charlotte A.,, Lerg, Charlotte A., Weiß, Jana, Lund University., Östling, Johan,, Weiß, Jana,, Östling, Johan   +10 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Re-thinking the role of intellectual property [PDF]

, 2013
The context in which intellectual property (IP) operates in the contemporary world is vastly different from the one in which IP was born.   The new context has changed the position of IP both in the economy and in society.
Francis Gurry
core  

Teaching Public History in UK Higher Education

, 2022
About this event Welcome: The AHRC-funded 'What is Public History Now?' Network is thrilled to invite you to our first workshop 'Teaching Public History in UK Higher Education'.
CAUVIN, Thomas
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source