Results 61 to 70 of about 282,443 (260)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Richard Whatmore, What is Intellectual History?

Prismas, 2017
Richard Whatmore, What is Intellectual History?, Cambridge, UK, Polity, 2015, 180 ...
Jani Marjanen
doaj  

Arthur Neiva e a 'questão nacional' nos anos 1910 e 1920 Arthur Neiva and the 'national question' in the 1910s and 1920s

História, Ciências, Saúde: Manguinhos, 2009
Com o objetivo de analisar as interpretações e os diagnósticos sobre o Brasil elaborados pelo cientista e escritor Arthur Neiva entre as décadas de 1910 e 1920, especialmente a partir de suas crônicas literárias e do relatório da expedição científica ...
Vanderlei Sebastião de Souza
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Odzyskać liberalizm. Recenzja książki Andrzeja Walickiego "Od projektu komunistycznego do neoliberalnej utopii", Warszawa: Universitas 2013

Studia Litteraria et Historica, 2016
To Recover Liberalism. Review of a book by Andrzej Walicki Od projektu komunistycznego do neoliberalnej utopii (From the Communist Project to the Neoliberal Utopia), Warszawa: Universitas 2013 This review discusses a recent book by Andrzej Walicki, Od ...
Małgorzata Fidelis
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Teaching American Studies within Intellectual History (idéhistoria)

American Studies in Scandinavia
This article reflects on the author’s experience of creating and teaching a set of courses with North American themes within the academic discipline of idéhistoria, intellectual history, at a Swedish university.
David Östlund
doaj   +1 more source

Intellectual History and Helsinki: Editorial Introduction

, 2020
[Extract] It is our great pleasure to present this first issue of the Yearbook of the Helsinki Centre for Intellectual History. Entitled Passions, Politics and the Limits of Society, this book brings together in a single volume a range of essays that engage with the changing shape of moral and political inquiry in the early modern period.
Haara, Heikki, Stapelbroek, Koen
openaire   +3 more sources