Results 51 to 60 of about 9,284,085 (237)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

The Justice of Balance: Understanding Intellectual Property from Chinese Historical and Philosophical Perspectives [PDF]

, 2007
PhDIn today's world, intellectual property is widely viewed as a threat to the public interest in using knowledge. As many scholars have argued, a theoretical reason accounting for this phenomenon is that traditional understanding of intellectual ...
Shao, Ke (Ken Yin-zhi Shao)
core   +2 more sources

Intellectual systems in education: history and prospects

Studia Humanitatis, 2018
The article considers intellect as a key concept that defines the essence of intelligent systems in general and information intelligent education systems in particular. The authors identified the main signs of intelligence that define information systems
Markaryan Anna Oganesovna, Haraberjush Ivan Fedorovych   +1 more
doaj   +1 more source

The Challenges of Intellectual Property Legal History Research

, 2020
This chapter considers the challenges of undertaking historical research into intellectual property law, from physical, intellectual and methodological challenges, through to challenges of reaching the right audience and conveying relevance.
Isabella Alexander, Alexander, I
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Sinology: Chinese Intellectual History and Transcultural Studies

The Journal of Transcultural Studies, 2017
In this article I attempt to identify some methodological connections between Chinese intellectual history and transcultural studies in Euro-American academia.
Pablo Blitstein
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

L’américanisation d’un intellectuel français : le cas d’Yves Simon (1903-1961)

Transatlantica, 2014
In 1938, Yves Simon, who taught philosophy at the Paris and Lille Catholic Institutes, received an invitation to teach at Notre Dame University in Indiana.
Florian Michel
doaj   +1 more source

What's the Big Idea? Intellectual History and the Longue Durée [PDF]

, 2012
Historians of all kinds are beginning to return to temporally expansive studies after decades of aversion and neglect. There are even signs that intellectual historians are returning to the longue durée.
Armitage, David
core   +1 more source