Results 41 to 50 of about 1,561,699 (304)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Analytical Concepts for Transcultural Settings: Pathways in Global Intellectual History

Cromohs: Cyber Review of Modern Historiography
In global intellectual history, there exists a tension between analytical concepts often carrying a Western or colonial pedigree and their ability to capture the multifaceted reality of historical actors who cannot be placed in one language or culture ...
Luc Wodzicki, Sebastian Conrad
doaj   +1 more source

Illustriousness in the farmhouse villa: reading virtue from a Flemish-Veronese merchant family's history [PDF]

, 2011
The Italian nobility has a long history tied to landownership, a dynamic example of which lies in the history of Verona from the late sixteenth century.
Dewhirst, Catherine
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Augustine’s Paradigm ’ab exterioribus ad interiora, ab inferioribus ad superiora’ in the Western and Eastern Christian Mysticism [PDF]

, 2015
I argue that St. Augustine of Hippo was the first in the history of Christian spirituality who expressed a key tendency of Christian mysticism, which implies a gradual intellectual ascent of the human soul to God, consisting of the three main stages ...
Alexey, Fokin
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Warren J. Samuels (1933-2011) [PDF]

, 2012
This paper examines the research and career of the late Warren J. Samuels (1933-2011), an influential institutionalist economist in the Wisconsin John Commons tradition and well-known historian and methodologist of economics.
Davis, John B.
core   +1 more source

The changing of the guard: groupwork with people who have intellectual disabilities [PDF]

, 2009
This paper considers the impact of service systems on group activities. It describes an inter-professional groupwork project facilitated by a social worker and a community nurse.
A. McClimens, A. Mullender, B. Nirje, B.W. Tuckman, C. Barnes, C.J.G. Gersick, D. Cardore, D. Herd, D. Ward, D.G. Race, F. Kevan, H. Northen, J. Edge, J. Walmsley, J. Walmsley, K. Nichols, L. Staples, M. Cohen, M. Doel, M. Preston-Shoot, P. Reason, P. Trevithick, P. Williams, R. Burke, R. Smith, R. Townsley, R.J. Stancliffe, S-J. Hays, S. Read, S. Russell, S.H. Chia, T. MacKay, T. Tyson, W. Utting   +33 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Intellectual systems in education: history and prospects

Studia Humanitatis, 2018
The article considers intellect as a key concept that defines the essence of intelligent systems in general and information intelligent education systems in particular. The authors identified the main signs of intelligence that define information systems
Markaryan Anna Oganesovna, Haraberjush Ivan Fedorovych   +1 more
doaj   +1 more source