Results 21 to 30 of about 1,019,563 (296)

THE CATEGORY OF BLINDNESS IN THE RECEPTIVE RESEARCH EXPERIENCE (BASED ON ELEONOR PORTER’S NOVEL “DAWN”)

Освітній дискурс
Relevance of the research. The article explores the category of blindness from historical, cultural, philosophical, and literary perspectives, using the example of Eleanor Porter’s lesser-known novel “Dawn”, which has not yet been widely studied in ...
Uliana Zhornokui, Kovalenko Natalia, Lidiia Pokotylo   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

PECULIARITIES OF USE OF ENTERTAINMENT CONTENT PLATFORMS IN THE EDUCATIONAL PROCESS

Освітній дискурс
Relevance of the research is due to the crucial educational role in universities and the importance of successful educational process organization which is based on the features of the use of social networks and entertainment content platforms in the ...
Lidiia Pokotylo, Uliana Zhornokui, Natalia Kovalenko   +2 more
doaj   +1 more source

Chemical Engineering Software and Legal Protection Thereof [PDF]

Journal of Petroleum Science and Technology, 2011
In recent years, an increasing number of Chemical Engineering Software (CES), which play an important role in improving efficiency in the petroleum industry, has been introduced to the                market.
Maryam Tavakol moghadam, Kamran Bagheri
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The Role of Intellectual Property in Developing a Knowledge-Based Society

Management, 2014
A long-time dominant position of protective features in the intellectual property (IP) rights has been neutralized by their commercializing possibilities. Patents, trademarks and other forms of IP are increasingly being seen as trading assets rather than
Branka Bilen-Katić, Nikola Radovanović
doaj   +1 more source

The New Innovation Frontier? Intellectual Property and the European Court of Human Rights [PDF]

, 2008
This article provides the first comprehensive analysis of the intellectual property case law of the European Court of Human Rights ( ECHR ). Within the last three years, the ECHR has issued a trio of intellectual property rulings interpreting the right ...
Helfer, Laurence R.
core   +1 more source