Results 31 to 40 of about 92,280 (267)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Enhancing legal collaborative governance for cross-border marine pollution in the Guangdong-Hong Kong-Macau Greater Bay Area: aligning rules, transforming mechanisms, and coordinating institutions

open access: yesFrontiers in Marine Science
Within the framework of “One Country, Two Systems and Three Legal Jurisdictions,” managing cross-regional marine pollution in the Guangdong-Hong Kong-Macau Greater Bay Area encounters significant legal obstacles, including inconsistent regulations ...
Weirong Chen   +3 more
doaj   +1 more source

Intellectual property and control

open access: yesAcademic Medicine, 1993
The issue of intellectual property is viewed differently by different groups involved in biomedical research: researchers; academic institutions; corporate, government, and philanthropic sponsors; and society. The members of these groups do not always agree even among themselves; within government and academe, for instance, there are different and ...
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Assessment of intellectual property management and technology commercialization in animal science research

open access: yesIndian Journal of Animal Sciences
To understand the innovation-based initiatives in the animal science sector, IP&TM Unit of ICAR has analysed IP management, and technology commercialization/licensing activities.
VIKRAM SINGH   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Legal Aspects of Nanobiotechnology Inventions: An Indian Perspective

open access: yesSCRIPTed: A Journal of Law, Technology & Society, 2009
Nanobiotechnology results from the convergence of nanotechnology and biotechnology. It has a remarkable potential to abate problems and provide efficient solutions related to medicine, the environment, agriculture etc. Nanobiotechnology applications have
Kanika Sharma, Archana Chugh
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

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