Results 51 to 60 of about 92,280 (267)
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
The Protection of Fashion Shows: An Uncharted Stage
Laws, 2019 The history of fashion shows goes back more than a century, and over the years, catwalks have gone from being private sales channels for a few wealthy customers to pure entertainment shows promoted globally.
Elena Varese, Valentina Mazza
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
PTNS: patent citation trajectory prediction based on temporal network snapshots
Scientific ReportsWith the rapid development of science and technology, the pace of development in the knowledge economy is accelerating. Intellectual property, especially patents, is a strategic resource for technological innovation and a crucial support for building an ...
Mingli Ding +3 more
doaj +1 more source
Journal of Intellectual PropertyThe efficiency of government-funded R&D support in South Korea appears to be in need of improvement. The amount of patent transfers and total technology royalty income has decreased drastically.
Jaeheon Lee +2 more
doaj +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Pitfalls of patenting and state authorization of medicines
Регуляторные исследования и экспертиза лекарственных средств, 2018 During the lifecycle of a medicine - from its development to consumption - the developer has to go through several stages, such as obtaining the exclusive right for a medicine, obtaining permission to produce the medicine, obtaining permission to ...
V. I. Semenov +2 more
doaj
Освітній дискурсRelevance of the research topic. Imagination as a psychological resource for managerial influence is of key importance in the context of the transformation processes in Ukrainian society, ensuring a balance between creativity and ethical leadership ...
Olga Kyvliuk, Oleksandr Khlon
doaj +1 more source
Advances in Antenna Technology for Wireless Handheld Devices
International Journal of Antennas and Propagation, 2013 The constant evolution of wireless handheld devices together with the apparition of multiple wireless communication systems fosters the antenna community to design new radiating and measurements systems capable of satisfying the market demands.
Jaume Anguera +5 more
doaj +1 more source