Results 71 to 80 of about 2,189,156 (303)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The Relationship between Geographical Indication Products and Farmers’ Incomes Based on Meta-Analysis

Agriculture
Geographical indication (GI) products serve as one of the significant instruments for increasing farmers’ income. While most studies affirmatively indicate that GI products contribute to boosting farmers’ income growth, it is noteworthy that their ...
Chunyan Li, Qi Ban, Lanqing Ge, Liwen Qi, Chenchen Fan   +4 more
doaj   +1 more source

Reparative approach Towards victims of armed Conflict: global experiences and lessons for india

BRICS Law Journal, 2019
In recent years, relentless efforts have been made worldwide for repairing the past harms done to victims of armed conflict. There has been a paradigm shift in international human rights law to addressing the victims’ need for reparation rather than ...
B. Sonowal, D. Dube
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Anticompetitive effect of drug name trademark registration: lessons from China

Humanities & Social Sciences Communications
The Chinese Trademark Law does not entirely exclude the possibility of generic names being registered as trademarks, which is inconsistent with the international standards.
Jun Shen, Xiaoting Song
doaj   +1 more source

Interfaces of intellectual property rights, perceptions, attitudes, research, and technology transfer in agricultural biotechnology and GMOs: Insights from Ethiopian researchers

Sustainable Futures
Several challenges hinder the adoption of agricultural biotechnologies and GMOs to alleviate food insecurity in developing countries. Intellectual property rights (IPR) in the sector and stakeholders’ perceptions and attitudes towards these technologies ...
Tadesse Kenea Amentae, Xue Zhang, Wei Song   +2 more
doaj   +1 more source

Bilateralism in Intellectual Property [PDF]

, 2001
This paper examines the way in which bilateral trade negotiations (Bilateral Investment Treaties and Bilateral Intellectual Property Agreements) are being used by the USA and others to build more extensive protection for intellectual property than that ...
Drahos, Peter
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source