Results 61 to 70 of about 1,965,771 (247)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

The impact of patent infringement litigation decisions on firms’ innovation performance in China

open access: yesScientific Reports
The judiciary protects the value of innovation through remedies such as injunctions and damages when patent rights are infringed, adjusting the expected returns on future innovation activities for firms. Based on data from 1,062 Chinese firms involved in
Yuting Deng, Yong Qi, Qing Guo
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

The Protection of Fashion Shows: An Uncharted Stage

open access: yesLaws, 2019
The history of fashion shows goes back more than a century, and over the years, catwalks have gone from being private sales channels for a few wealthy customers to pure entertainment shows promoted globally.
Elena Varese, Valentina Mazza
doaj   +1 more source

Knowledge management as intellectual property: Evidence from Mexican manufacturing SMEs [PDF]

open access: yes, 2016
© 2016, © Emerald Group Publishing Limited. Purpose: The purpose of this paper is to explore the relationship between knowledge management and creation of intellectual property within the context of small and medium size manufacturing enterprises. Design/
Kumar, Vikas   +5 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

THE THEORETICAL AND METHODOLOGICAL POTENTIAL OF IMAGINATION IN THE ACTIVITIES OF A LAW-ABIDING MANAGER WHEN EXERCISING MANAGERIAL INFLUENCE

open access: yesОсвітній дискурс
Relevance of the research topic. Imagination as a psychological resource for managerial influence is of key importance in the context of the transformation processes in Ukrainian society, ensuring a balance between creativity and ethical leadership ...
Olga Kyvliuk, Oleksandr Khlon
doaj   +1 more source

Submission to the Advisory Council on Intellectual Property on Plant Breeders' Rights Enforcement [PDF]

open access: yes, 2007
In my opinion, the Advisory Council on Intellectual Property should investigate whether it is feasible and viable to implement a legislative scheme for the collective administration of plant breeders’ rights.
Rimmer, Matthew
core  

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

PTNS: patent citation trajectory prediction based on temporal network snapshots

open access: yesScientific Reports
With the rapid development of science and technology, the pace of development in the knowledge economy is accelerating. Intellectual property, especially patents, is a strategic resource for technological innovation and a crucial support for building an ...
Mingli Ding   +3 more
doaj   +1 more source

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