Results 41 to 50 of about 1,019,563 (296)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

PHILOSOPHY OF WAR AND TRANSFORMATION OF CULTURAL VALUES IN CONDITIONS OF ARMED CONFLICT

Освітній дискурс
Relevance of the research. The phenomenon of war is one of the most profound and tragic themes in the philosophical reflection on human existence.
Svitlana Solianyk, Olena Nevmerzhytska
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

THEORETICAL AND METHODOLOGICAL PROBLEMS OF PSYCHOLOGICAL RESEARCH OF PERSONALITY ON THE EXAMPLE OF STUDYING THE CONFLICT BETWEEN THE ALTER EGO AND THE SUPEREGO IN INTRAPERSONAL COMMUNICATION

Освітній дискурс
Relevance of the research topic. The study of intrapersonal communication, in particular the conflict between the alter ego and the super ego of the subject, is extremely relevant in the context of modern socio-political and psychosocial conditions that ...
Olga Kyvliuk, Oleksandr Khlon
doaj   +1 more source

Mentorship program to elevate journal quality and rankings in Indonesia: a case study [PDF]

Science Editing
This article explores the best practices of mentorship programs in all journals at Universitas Airlangga. The university has established a journal mentoring team, as mandated by the rector’s regulation, which is responsible for guiding journals through ...
Ferry Efendi, Hery Purnobasuki, Dessy Harisanty, Diyah Alinia Oktariningtias, Sarah Khairunnisa   +4 more
doaj   +1 more source

Intellectual property and control

Academic Medicine, 1993
The issue of intellectual property is viewed differently by different groups involved in biomedical research: researchers; academic institutions; corporate, government, and philanthropic sponsors; and society. The members of these groups do not always agree even among themselves; within government and academe, for instance, there are different and ...
openaire   +4 more sources

A Review of Intellectual Property Protection within the CGIAR [PDF]

, 1993
Report of the Center Directors' Committee on Intellectual Property Rights transmitted to those attending ICW93 as background for a panel discussion on IPR and implications for IARCs. The report reviews the various steps taken by the centers and the CGIAR
CGIAR Center Directors Committee on Intellectual Property Rights
core  

Mechanical Timepieces & Intellectual Property Protection [PDF]

, 2018
This article is meant to give you a basic understanding of mechanical timepieces—not just what they are, but how they are different from one another and why that difference is significant.
Douglas, Nicholas
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source