Results 31 to 40 of about 139,740 (305)

PROBLEMS OF INHERITANCE OF INTELLECTUAL RIGHTS TO THE RESULTS OF CREATIVE ACTIVITY AND EQUIVALENT OBJECTS

Гуманитарные и юридические исследования, 2021
In connection with the special nature of intellectual rights to the results of creative activity and objects equated to them, there are certain features of their transition in the order of inheritance, as well as registration of the rights of heirs, not ...
Marina Melnikova, Viktoriia Savina
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Terrorism and Intellectual Property Rights

AMA Journal of Ethics, 2004
A bioethicist argues that the government has the right to restrict or override intellectual property rights in response to a national emergency only when specific criteria are met. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The strength of intellectual property protection, corporate financing constraints, and corporate governance efficiency: Mechanisms and heterogeneity analysis

International Review of Economics & Finance
This paper aims to conduct an in-depth investigation into the complex relationship among the strength of intellectual property protection, corporate financing constraints, and corporate governance efficiency. To this end, it selects Chinese non-financial
Dong Wang, Bibo Ding
doaj   +1 more source

The multidimensional legal nature of personal genomic sequence data: A South African perspective

Frontiers in Genetics, 2022
This article provides a comprehensive analysis of the various dimensions in South African law applicable to personal genomic sequence data. This analysis includes property rights, personality rights, and intellectual property rights.
Donrich W. Thaldar, Beverley A. Townsend, Beverley A. Townsend, Dusty-Lee Donnelly, Marietjie Botes, Marietjie Botes, Amy Gooden, Joanne van Harmelen, Bonginkosi Shozi, Bonginkosi Shozi   +9 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Health and intellectual property rights

Ceylon Medical Journal, 2014
مجلة سيلان الطبية (CMJ) هي مجلة خاضعة لمراجعة الأقران ومفتوحة الوصول تنشرها الجمعية الطبية السريلانكية كل ثلاثة أشهر في الأسبوع الأخير من مارس ويونيو وسبتمبر وديسمبر من كل عام. تتمثل مهمة CMJ في تعزيز علم وفن الطب وتحسين الصحة العامة. تنشر المجلة أوراقًا وتعليقات أصلية ذات صلة بالطب والعلوم المرتبطة به.
openaire   +4 more sources