Results 41 to 50 of about 1,142,480 (292)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The multidimensional legal nature of personal genomic sequence data: A South African perspective

Frontiers in Genetics, 2022
This article provides a comprehensive analysis of the various dimensions in South African law applicable to personal genomic sequence data. This analysis includes property rights, personality rights, and intellectual property rights.
Donrich W. Thaldar, Beverley A. Townsend, Beverley A. Townsend, Dusty-Lee Donnelly, Marietjie Botes, Marietjie Botes, Amy Gooden, Joanne van Harmelen, Bonginkosi Shozi, Bonginkosi Shozi   +9 more
doaj   +1 more source

Knowledge disclosure as intellectual property rights [PDF]

, 2007
We study a model in which an inventor discloses knowledge about its innovation and then a rival chooses the probability of attaining a competing invention.
Ponce, Carlos J.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The construction of ‘invalidation of intellectual property rights’ as a way to protect the right: a tragic experience of catharsis

Теорія і практика інтелектуальної власності
When considering disputes in the field of intellectual property, a method of protecting subjective rights is often used, such as declaring a legal fact that establishes an intellectual property right invalid.
Serhii Vavzhenchuk
doaj   +1 more source

Intellectual Property Rights

Scholars Journal of Engineering and Technology
In this current rapidly evolving technological era, the fear and threat of theft, fraud and infringement looms large in the virtual Diasporas. The creativity of an inventor/creator is dependent on the originality quotient of his or her work. Greater the uniqueness greater is the value of the work. Hence, the need of protection arises.
Ms Sanskriti Tripathy, Shankar Das, Dharmendra Pratap Singh, Bipin Jojo, Rakesh Dwivedi, D. R. Sahu, Byomakesh Tripathy, Mohini Gautam, Mrs. Anjali Tripathy, Tridibesh Tripathy   +9 more
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Introduction of intellectual Property Rights and its related issues An Analytical Study in Islamic Perspective = حقوق دانش کا تعارف اوراس کے متعلقہ مسائل اسلامی تناظر میں ایک تجزیاتی مطالعہ [PDF]

Hazara Islamicus, 2017
Patents, Copyrights, Trademarks and other artistic works are declared world wide as intellectual Property of its inventor. World Intellectual Property Organization (WIPO) and Intellectual Property Origination (IPO) Pakistan are well known organizations ...
Dr Junaid Akbar, Sanaullah
doaj