Results 41 to 50 of about 357,716 (311)

In defence of virtue epistemology [PDF]

open access: yes, 2011
In a number of recent papers Duncan Pritchard argues that virtue epistemology’s central ability condition—one knows that p if and only if one has attained cognitive success (true belief) because of the exercise of intellectual ability—is neither ...
Kelp, Christoph
core   +1 more source

DEEP DISAGREEMENTS ON VALUES, JUSTICE, AND MORAL ISSUES: TOWARDS AN ETHICS OF DISAGREEMENT [PDF]

open access: yesTrames, 2020
Scholars have long recognized the existence of myriad widespread deep disagreements on values, justice, morality, and ethics. In order to come to terms with such deep disagreements, resistant to rational solution, this article asserts the need for ...
Manuel Knoll
doaj   +1 more source

Understanding as an Intellectual Virtue [PDF]

open access: yes, 2019
In this paper I elucidate various ways in which understanding can be seen as an excellence of the mind or intellectual virtue. Along the way, I take up the neglected issue of what it might mean to be an “understanding person”—by which I mean not a ...
Grimm, Stephen
core  

Cosmic Gratitude [PDF]

open access: yes, 2014
Classically, gratitude is a tri-polar construal, logically ordering a benefactor, a benefice, and a beneficiary in a favour-giving-receiving situation. Grammatically, the poles are distinguished and bound together by the prepositions ”to’ and ”for’; so I
Roberts, Robert C.
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

The Transculturality of Virtue in the Early Modern Mediterranean: A Case Study in Florentine-Ottoman Relations

open access: yesCromohs: Cyber Review of Modern Historiography
This article approaches the transculturality of virtue ethics in early modern Mediterranean intellectual culture by focusing on the case study of Florentine-Ottoman relations during the reign of Sultan Mehmed II.
Luc Wodzicki
doaj   +1 more source

Illustriousness in the farmhouse villa: reading virtue from a Flemish-Veronese merchant family's history [PDF]

open access: yes, 2011
The Italian nobility has a long history tied to landownership, a dynamic example of which lies in the history of Verona from the late sixteenth century.
Dewhirst, Catherine
core   +1 more source

Testimony, Faith and Humility [PDF]

open access: yes, 2020
© Cambridge University Press 2020.It is sometimes claimed that faith is a virtue. To what extent faith is a virtue depends on what faith is. One construal of faith, which has been popular in both recent and historical work on faith, is that faith is a ...
Malcolm, Finlay
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz   +11 more
wiley   +1 more source

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