Results 101 to 110 of about 50,093 (313)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

Celluloid Bodies: Images of Intellectuals in Film

open access: yes, 2000
This chapter examines the image of intellectuals in film. Films mentioned include Lolita, The Browning Version, Star Trek Next Generation, No Regrets for our Youth, Providence, Mon Oncle d ...
O'Farrell, Clare D.
core  

МОВА У ПОВСЯКДЕННОМУ СПІЛКУВАННІ УКРАЇНСЬКОЇ ІНТЕЛІГЕНЦІЇ (ДРУГА ПОЛОВИНА ХІХ СТОЛІТТЯ) / EVERYDAY LANGUAGE OF THE UKRAINIAN INTELLECTUALS IN THE LATE 19TH CENTURY

open access: yesАктуальні питання суспільних наук та історії медицини, 2017
Казакевич Ольга. Мова у повсякденному спілкуванні української інтелігенції (друга половина ХІХ століття) У статті проаналізовано причини та фактори вливу на свідоме використання української мови у повсякденному вжитку на родинному рівні та у ...
Ольга КАЗАКЕВИЧ
doaj   +1 more source

Intellectual Isolation

open access: yesMind, 2018
Intellectualism is the widespread view that practical reason is a species of theoretical reason, distinguished from others by its objects: reasons to act. I argue that if practical reason is a species of theoretical reason, practical judgments by nature have nothing to do with action.
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Intellectuals under fire [PDF]

open access: yes, 2004
Looks at the status of intellectuals in South Africa ten years after democracy was established in the country. Direction of democracy in the country; Concerns about the policies of the government and its response to criticism from ...
Jansen, Jonathan, Jansen, Jonathan D.
core  

Sur la circulation du modèle corporatif fasciste dans le monde : agents, réseaux, effets

open access: yesLaboratoire Italien
Recent historiography on the transnational dimension of fascism has attributed a role of primary importance to the circulation of the corporatist model that Mussolini’s regime began to construct from the mid-1920s onwards.
Matteo Pasetti
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Indroduction. Italian intellectuals and international politics

open access: yes, 2019
Through the prism of one of the most original personalities of economic culture and Italian politics of the 1970s-1990s, the contribution aims to investigate the theme of international politics as a mirror of the country’s conflictual identity and ...
Guiso
core  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

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