Results 91 to 100 of about 71,613 (303)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Thinking Jewish Modernity in the Feminine: Jewish Women Intellectuals in the 20th and 21st Century

, 2018
The conference Thinking Jewish Modernity in the Feminine will explore how 20th and 21st century women intellectuals and authors from Else Lasker-Schüler to Helène Cixous more or less explicitly redefined their own identity as Jewish women intellectuals.
Ombrosi, Orietta
core  

Gramsci, os intelectuais e suas funções científico-filosófica, educativo-cultural e política Gramsci, the intellectuals and their scientific-philosophical, educational-cultural and political roles

Pro-Posições, 2011
À luz da concepção gramsciana de intelectual, vista sob o prisma do engajamento político, o texto apresenta uma leitura de suas funções científico-filosófica, educativo-cultural e política, na disputa pela hegemonia que se trava entre as classes na ...
Marcos Francisco Martins
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A Perspective on Intellectuals [PDF]

, 2010
We researched the role of the intellectual in contemporary society, focusing on Sartre’s definition of an intellectual and on Lyotard’s critizism of that.
Dmitriew, Lisa, Illum, Signe, Ehrlich, Lisa, Kristiansen, Anders   +3 more
core  

Analog Intellectuals

, 2012
I seem to have lost touch with the digital world lately. Have not encoded in weeks, have not made any inner progress concerning the structure of the corpora, have not moved on one bit in my reflexions concerning the search engine and am not really sure ...
Anne Baillot
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Crossing the walls between disciplines in the 21st century

Anales del Seminario de Historia de la Filosofía
These unpublished dialogues were constructed throughout 2024, is a document that attempts to contribute to the complex and diverse terrain of the History of Ideas of the XXI Century.
Nicol A. Barria-Asenjo, Jacques Rancière   +1 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source