Results 81 to 90 of about 71,613 (303)
Italian Intellectuals and International Politics, 1945–1992 [electronic resource] /
, 2019 Italian intellectuals played an important role in the shaping of international politics during the Cold War. The visions of the world that they promulgated, their influence on public opinion and their ability to shape collective speech, whether in ...
Tarquini, Alessandra.editor.edthttp://id.loc.gov/vocabulary/relators/edt +3 more
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Intellectuals and Communism [PDF]
, 2017 first para: Grappling with the relationship between intellectuals and communism after 1917 calls to mind two topics long treated as almost entirely distinct.
Michael David-Fox
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The Limits of Anti-Nuclear Critique in Pakistan
Journal for Peace and Nuclear DisarmamentPakistan has a long history of social movements, some of which have challenged the military’s domination. However, apart from a short period after 1998 nuclear weapon tests by India and Pakistan, there has been limited opposition to nuclear weapons owned
Sadia Tasleem, M. V. Ramana
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
, 2017 This essay explores the social and political role and significance of the intellectuals within capitalist society. It sets out to define the intellectual and the nature of what they produce (ideas) and their relationship to broader class relations.
Deirdre O’Neill +3 more
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Intellectuals under fire [PDF]
, 2004 Looks at the status of intellectuals in South Africa ten years after democracy was established in the country. Direction of democracy in the country; Concerns about the policies of the government and its response to criticism from ...
Jansen, Jonathan, Jansen, Jonathan D.
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Київські історичні студіїThe paper examines the processes that took place in the literary and artistic milieu in Soviet Ukraine. The primary approach employed in this study is an assessment of this period considering the socio-political events of the 1920s.
Oleksandr Bon
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