Results 61 to 70 of about 50,093 (313)
Stella Gibbons, ex-centricity and the suburb
, 2009 In The Intellectuals and the Masses (1992), John Carey writes: 'The rejection by intellectuals of the clerks and the suburbs meant that writers intent on finding an eccentric voice could do so by colonizing this abandoned territory.
Hammill, Faye, Faye Hammill
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Italian Intellectuals and International Politics [PDF]
, 2019 This book brings together contributions from historians of different cultural and methodological backgrounds, gathered around a common idea: understanding how Italian intellectuals interpreted, discussed and influenced international politics between the ...
Alessandra Tarquini
core
Solidarity and Italian Labor Movement Culture: CGIL Intellectuals and Revision of the CGIL’s International Relations (1980–1982) [PDF]
, 2019 The contribution aims to highlight the influence of the movement of Solidarność on the largest Italian trade union, the General Confederation of Labor during the peak of the Polish crisis (1980–1982).
Enrico Serventi Longhi
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Intellectuals and Communism [PDF]
, 2017 first para: Grappling with the relationship between intellectuals and communism after 1917 calls to mind two topics long treated as almost entirely distinct.
Michael David-Fox
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Intellectual Integrity as Intellectual Virtue
Siberian Journal of Philosophy, 2020 In this paper, I examine intellectual integrity as one of the possible intellectual virtues. I also try to investigate the opposite notion, intellectual dishonesty. I conclude that intellectual dishonesty does not necessarily entail dishonesty in the moral sense, but just presupposes that an agent has her interest in a certain outcome of her research ...
openaire +2 more sources
The Intellectuals and the Virtues [PDF]
Ethics, 2015 A virtuous person has a distinctive grasp of what is important in the light of which she chooses what to do. In what does this grasp consist? According to the intellectual tradition, moral virtue requires you always to be able to have an explicit, conscious grasp of the reasons why your action is right.
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source