Results 51 to 60 of about 257,980 (292)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The Anatomy of a Regicide Attempt: Shāhrukh, the Ḥurūfīs, and the Timurid Intellectuals in 830/1426–27 [PDF]

, 2013
This article provides a contextual analysis of the assassination attempt on the Timurid ruler Shahrukh’s life on 21 February 1427 in Herat. According to the contemporary Timurid chroniclers, Ahmad-i Lur, a Hurufi by profession, tried to kill ...
Afshār, Afshār, Aka, Algar, Allen, Ando, Anvār, Ateş, Barthold, Bartol'd, Bashir, Bashir, Bayānī, Bihbahānī, Brend, Browne, Cooke, Diler, Fazlıoğlu, Fleischer, Goldziher, Golombek, Gölpınarlı, Gölpınarlı, Haase, İLKER EVRİM BİNBAŞ, Imām, Jāmī, Khiyāvī, Khvārazmī, Kirmānī, Kiyā, Kuli-Zade, Köle, Köprülü, Lentz, Melville, Netton, Ni'matī, Paul, Roemer, Sachau, Savory, Subtelny, Tauer, Tauer, Tauer, Trimingham, Usluer, Woods, Yüksel, Āzhand, Ṣafā, Ṭabasī, ‘Abbāsī, ‘Abdallāh Vā’iẓ   +55 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Cultural Cold War and 1939 Republican Exile: the World Congress of Intellectuals in Defense of Peace (Wroclaw, 1948)

Culture & History Digital Journal, 2018
The cultural battle between the USA and the Soviet Union belongs to the chapters of the Cold War held by the two superpowers in the aftermath of World War II. This article studies how the intellectuals of the 1939 Republican exile took part in the Soviet
Manuel Aznar Soler
doaj   +1 more source

Intellectuals and Communism [PDF]

, 2017
first para: Grappling with the relationship between intellectuals and communism after 1917 calls to mind two topics long treated as almost entirely distinct.
Michael David-Fox
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Hong Kong\u27s democratic movement and the making of China\u27s offshore civil society

, 2012
Hong Kong\u27s civil society has remained vibrant since the sovereignty handover in 1997, thanks to an active defense by the democratic movement against Beijing\u27s attempts to control civil liberties.
HUNG, Ho Fung, IP, Iam Chong
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Mexican art exhibitions in New York as cultural diplomacy, 1928-1932 [PDF]

, 2016
In the aftermath of the 1910 Mexican Revolution, the postrevolutionary state launched an innovative campaign that exported the country’s emerging art and culture, which glorified its indigenous roots. The strategy of expanding its nation-building project
Rendon, Darcy
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source