Results 81 to 90 of about 2,492,609 (353)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Tailoring the effect of antithrombin-targeting therapy in haemophilia A using in silico thrombin generation

Scientific Reports, 2021
Factor (F) VIII deficiency causes bleeding in haemophilia A patients because of the reduced formation of procoagulant enzyme thrombin, which is needed to make the blood clot.
Romy M. W. de Laat-Kremers, Marisa Ninivaggi, Iris van Moort, Moniek de Maat, Bas de Laat   +4 more
doaj   +1 more source

Quantum Aspects of Semantic Analysis and Symbolic Artificial Intelligence

, 2004
Modern approaches to semanic analysis if reformulated as Hilbert-space problems reveal formal structures known from quantum mechanics. Similar situation is found in distributed representations of cognitive structures developed for the purposes of neural ...
, Aerts D, Aerts D, Aerts D Czachor M, Bell J S, Bennett C H Brassard G, Bettelli S, Blei D M, Bush P, Deerwester S, Diederik Aerts, Griffiths T L, Hampton J, Hofmann T, Landauer T K, Landauer T K, Landauer T K, Lund K, Marek Czachor, Oemer B, Penrose R, Penrose R, Penrose R, Plate T A, Selinger P, Steyvers M Shiffrin R M Nelson D L, Widdows D Peters S R T Oehrle J Rogers   +26 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Beyond general self-efficacy beliefs and big-five personality traits in teacher burnout: the role of emotional intelligence [PDF]

, 2015
Introduction: Prior research has underlined the key role that specific personal resources such as generalized self-efficacy and Big-Five traits play in the process of burnout.
Extremera, Natalio, Pelaez-Fernandez, Maria Angeles, Rey-Peña, Lourdes   +2 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The Analyst’s Hierarchy of Needs: Grounded Design Principles for Tailored Intelligence Analysis Tools

Analytics
Intelligence analysis involves gathering, analyzing, and interpreting vast amounts of information from diverse sources to generate accurate and timely insights.
Antonio E. Girona, James C. Peters, Wenyuan Wang, R. Jordan Crouser   +3 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source