Results 61 to 70 of about 2,492,609 (353)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Reconstructing the medical intelligence framework: an integration of the health-risk approach into the process of intelligence analysis

Global Security: Health, Science and Policy
The increasing prevalence of threats within the health domain has urged the establishment of the medical intelligence field. As the first line of the health security system, medical intelligence focuses on detecting and preventing health-related threats,
Budi Gunawan, Barito Mulyo Ratmono, Ede Surya Darmawan, Fajar Fauzian Samstaga Kartasasmita   +3 more
doaj   +1 more source

Escherichia coli resistance, treatment patterns and clinical outcomes among females with uUTI in Germany: a retrospective physician-based chart review study

Scientific Reports, 2023
Real-world data were collected to examine antimicrobial resistance (AMR) prevalence, treatment patterns, and clinical outcomes among female patients with uncomplicated urinary tract infection (uUTI) in Germany.
Kurt G. Naber, Florian Wagenlehner, Michael Kresken, Wendy Y. Cheng, Maryaline Catillon, Mei Sheng Duh, Louise Yu, Anamika Khanal, Aruni Mulgirigama, Ashish V. Joshi, Shinyoung Ju, Fanny S. Mitrani-Gold   +11 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

SEVEN ANALYTICAL COMMANDMENTS (I) [PDF]

Romanian Intelligence Studies Review
Intelligence organisations focus on methodology and methodology-related issues. However, there is one more important thing that should also be discussed and this is ethics. Both elements are inextricably linked, and they should be presented and described
Józef KOZLOWSKI
doaj  

Explainable Document Classification via Concept Whitening and Stable Graph Patterns

IEEE Access
This paper proposes a novel explainable document classification framework that integrates Concept Whitening (CW) with graph concepts that are derived from stable graph patterns, and extracted via methods based on Formal Concept Analysis (FCA) and pattern
Eric George Parakal, Sergei O. Kuznetsov, Ilya Makarov, Nikita Severin   +3 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Cumbria Economic Bulletin - September 2010 [PDF]

, 2010
The Bulletin is jointly produced by the Centre for Regional Economic Development (CRED), at the University of Cumbria in Carlisle, and the Cumbria Intelligence Observatory (CIO). The aim of the Cumbria Intelligence Observatory (CIO) is to bring together
Bloomer, Daniel, Centre for Regional Economic Development (CRED), Cumbria Intelligence Observatory (CIO), Frank, Stuart, Jackson, Keith, Murphy, Ginny, Peck, Frank   +6 more
core  

Artificial intelligence in the cyber domain: Offense and defense [PDF]

, 2020
Artificial intelligence techniques have grown rapidly in recent years, and their applications in practice can be seen in many fields, ranging from facial recognition to image analysis.
Diep, Quoc Bao, Truong, Thanh Cong, Zelinka, Ivan   +2 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source