Results 41 to 50 of about 536,964 (263)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
SEVEN ANALYTICAL COMMANDMENTS (I) [PDF]
Romanian Intelligence Studies ReviewIntelligence organisations focus on methodology and methodology-related issues. However, there is one more important thing that should also be discussed and this is ethics. Both elements are inextricably linked, and they should be presented and described
Józef KOZLOWSKI
doaj
Explainable Document Classification via Concept Whitening and Stable Graph Patterns
IEEE AccessThis paper proposes a novel explainable document classification framework that integrates Concept Whitening (CW) with graph concepts that are derived from stable graph patterns, and extracted via methods based on Formal Concept Analysis (FCA) and pattern
Eric George Parakal +3 more
doaj +1 more source
CIE-LSCP: color image encryption scheme based on the lifting scheme and cross-component permutation
Complex & Intelligent Systems, 2022 Encryption of meaningful images into unidentifiable noise-like images can improve the security of images during storage and transmission. In this paper, a novel color image encryption method based on the lifting scheme and cross-component permutation ...
Xiuhui Chen +5 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
An artificial intelligence-based ecological index for prognostic evaluation of colorectal cancer
BMC Cancer, 2023 Background and objective In the tumor microenvironment (TME), the dynamic interaction between tumor cells and immune cells plays a critical role in predicting the prognosis of colorectal cancer.
Qicong Chen +11 more
doaj +1 more source