Results 41 to 50 of about 23,492,034 (304)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Global Security: Health, Science and PolicyThe increasing prevalence of threats within the health domain has urged the establishment of the medical intelligence field. As the first line of the health security system, medical intelligence focuses on detecting and preventing health-related threats,
Budi Gunawan +3 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
SEVEN ANALYTICAL COMMANDMENTS (I) [PDF]
Romanian Intelligence Studies ReviewIntelligence organisations focus on methodology and methodology-related issues. However, there is one more important thing that should also be discussed and this is ethics. Both elements are inextricably linked, and they should be presented and described
Józef KOZLOWSKI
doaj
Situational Awareness in the Third Nuclear Age
Scandinavian Journal of Military StudiesHow do the defining features of the third nuclear age shape requirements for strategic situational awareness? As states navigate contemporary escalation dynamics, they increasingly prioritize situational awareness to adapt to evolving technology and ...
Jamie Withorne
doaj +1 more source
Cross-Task Cognitive Workload Recognition Based on EEG and Domain Adaptation
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2022 Cognitive workload recognition is pivotal to maintain the operator’s health and prevent accidents in the human-robot interaction condition. So far, the focus of workload research is mostly restricted to a single task, yet cross-task cognitive ...
Yueying Zhou +6 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
National Intelligence Daily (Cable) 2 December 1982 [PDF]
, 1982 Declassified on 2017-11 ...
United States. Central Intelligence Agency. +1 more
core +1 more source
Explainable Document Classification via Concept Whitening and Stable Graph Patterns
IEEE AccessThis paper proposes a novel explainable document classification framework that integrates Concept Whitening (CW) with graph concepts that are derived from stable graph patterns, and extracted via methods based on Formal Concept Analysis (FCA) and pattern
Eric George Parakal +3 more
doaj +1 more source