Results 41 to 50 of about 1,192,098 (294)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Pre-Dog-Leg: A Feature Optimization Method for Visual Inertial SLAM Based on Adaptive Preconditions

open access: yesSensors
To address the ill-posedness of the Hessian matrix in monocular visual-inertial SLAM (Simultaneous Localization and Mapping) caused by unobservable depth of feature points, which leads to convergence difficulties and reduced robustness, this paper ...
Junyang Zhao   +6 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Intelligent Adaptive Motion Control for Ground Wheeled Vehicles [PDF]

open access: yes, 2014
In this paper a new intelligent adaptive control is applied to solve a problem of motion control of ground vehicles with two independent wheels actuated by a differential drive.
MELLUSO, Maurizio
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

An Intelligent Gated Fusion Network for Waterbody Recognition in Multispectral Remote Sensing Imagery

open access: yesRemote Sensing
Accurate water body segmentation from multispectral remote sensing imagery is critical for hydrological monitoring and environmental management. However, leveraging transfer learning with pre-trained models remains challenging due to the dimensional ...
Tong Zhao   +3 more
doaj   +1 more source

Intelligent Control [PDF]

open access: yes, 2010
Our goal is to search for intelligent control techniques that improve the performance of the controller and reduce the computation burden. The main idea here is to combine two control techniques, nonlinear control and neural network control. The new adaptive neural control strategy presented is a combination of two controllers.
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Deciphering spatial domains from spatially resolved transcriptomics through spatially regularized deep graph networks

open access: yesBMC Genomics
Background Recent advancements in spatially resolved transcriptomics (SRT) have opened up unprecedented opportunities to explore gene expression patterns within spatial contexts.
Daoliang Zhang   +7 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

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