Results 41 to 50 of about 9,817,156 (285)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Is Intelligent Design Science? Dissecting the Dover Decision [PDF]

, 2006
In the case of Kitzmiller et al. v. Dover Area School District, et al., Judge Jones ruled that a pro-intelligent design disclaimer cannot be read to public school students.
Monton, Bradley
core  

Empiricism and Intelligent Design II: Analyzing Intelligent Design [PDF]

Erkenntnis, 2012
If intelligent design (id) is to compete with evolutionary theory (et), it must meet the modified falsifiability challenge, that is, make some deductive or probabilistic observational assertions. It must also meet the modified translatability challenge, which it fails if et makes all the observational assertions of id, while id does not make all the ...
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Nacre-Inspired Flexible Mxene-Based Films for Multifunctional Applications in Supercapacitors and Piezoresistive Sensors

Sensors
The explosive demand for flexible wearable and portable devices imposes stringent requirements on the mechanical, energy storage, and sensing properties of functional materials. Although two-dimensional (2D) transition metal carbides and nitrides (MXene)
Beibei Wang, Licheng Zhou, Sentao Wei, Qiuhang Zhu, Qun Wu, Chuan Cao   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Auxiliary Assumptions, Unification, and Intelligent Design: A Defense of Contrastive Testability [PDF]

, 2011
Boudry and Leuridan argue that in a number of cases—and specifically in the case of intelligent design—a theory can be intuitively testable, but not contrastively testable according to Sober’s definition.
Lutz, Sebastian
core  

Research progress on continuum topology optimization for lightweight structure design

Xibei Gongye Daxue Xuebao
In order to sort and study the continuum topology optimization methods in the lightweight design of mechanical structures, the main research results achieved in this field at home and abroad in recent years are analyzed and reviewed.
ZHANG Lei, KOU Ruoyang, YUE Zhibin, DONG Lei, TAN Xuening, WANG Guoqin, LI Xia   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Unified interest point detection and description for perspective and Fisheye images

Scientific Reports
Keypoint detection and descriptor matching are essential in tasks like feature matching, object tracking, and 3D reconstruction. While CNN-based methods have advanced these areas, most focus on perspective projection cameras, with limited consideration ...
Jian Xu, DeWei Han, Kang Li, JunJie Li, ZhaoYuan Ma   +4 more
doaj   +1 more source