Results 51 to 60 of about 1,450,640 (278)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Gait Recognition for Lower Limb Exoskeletons Based on Interactive Information Fusion

Applied Bionics and Biomechanics, 2022
In recent decades, although the research on gait recognition of lower limb exoskeleton robot has been widely developed, there are still limitations in rehabilitation training and clinical practice.
Wei Chen, Jun Li, Shanying Zhu, Xiaodong Zhang, Yutao Men, Hang Wu   +5 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

An improved electrocardiogram arrhythmia classification performance with feature optimization

BMC Medical Informatics and Decision Making
Background Automatic classification of arrhythmias based on electrocardiography (ECG) data faces several significant challenges, particularly due to the substantial volume of clinical data involved in ECG signal analysis.
Annisa Darmawahyuni, Siti Nurmaini, Bambang Tutuko, Muhammad Naufal Rachmatullah, Firdaus Firdaus, Ade Iriani Sapitri, Anggun Islami, Jordan Marcelino, Rendy Isdwanta, Muhammad Ikhwan Perwira   +9 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Computer-aided assessment for enlarged fetal heart with deep learning model

iScience
Summary: Enlarged fetal heart conditions may indicate congenital heart diseases or other complications, making early detection through prenatal ultrasound essential.
Siti Nurmaini, Ade Iriani Sapitri, Muhammad Taufik Roseno, Muhammad Naufal Rachmatullah, Putri Mirani, Nuswil Bernolian, Annisa Darmawahyuni, Bambang Tutuko, Firdaus Firdaus, Anggun Islami, Akhiar Wista Arum, Rio Bastian   +11 more
doaj   +1 more source

An Intelligent Auxiliary Vacuum Brake System [PDF]

, 2009
The purpose of this paper focuses on designing an intelligent, compact, reliable, and robust auxiliary vacuum brake system (VBS) with Kalman filter and self-diagnosis scheme.
Li, Jiun-Yi, Li, Shih-Fan, Lin, Jhih-Yu, Tong, Chia-Chang   +3 more
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Modeling and Vibration Analysis of a 3-UPU Parallel Vibration Isolation Platform with Linear Motors Based on MS-DT-TMM

Shock and Vibration, 2021
The dynamics and vibration characteristics of a 3-UPU parallel mechanism isolator are investigated by theoretical modeling, numerical simulation, and experimental study.
Wei Chen, Jiaqi Tong, Hehe Yang, Fulong Liu, Zhen Qin, Zhiyong Ren   +5 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source