Results 111 to 120 of about 296,353 (284)
Bottom-trapped currents as statistical equilibrium states above topographic anomalies [PDF]
, 2012 Oceanic geostrophic turbulence is mostly forced at the surface, yet strong bottom-trapped flows are commonly observed along topographic anomalies. Here we consider the case of a freely evolving, initially surface-intensified velocity field above a ...
A. Venaille, Gill, Maltrud
core +3 more sources
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
An evaluation of the workbook for health trainers in prisons and the wider community: based on the Royal Institute of Public Health Level 2 award: understanding health improvement [PDF]
, 2008 Health trainers form part of a public policy initiative designed to tackle health inequalities. Health Trainers were first proposed in the White Paper ‘Choosing Health’ (2004) and initially some 1200 NHS accredited Health Trainers were placed in post ...
Ball, Linda +2 more
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
PLoS ONE, 2019 One of the trends in today's tourism sector is the development of environmentally-friendly tourism activities which rely on natural resources of cultural heritage and on biodiversity.
Arkadiusz Sadowski +1 more
doaj +1 more source
Surviving and sustaining teaching excellence: A narrative of ‘entrapment’ [PDF]
, 2009 This paper discusses the key concepts of ‘surviving’ and ‘sustaining’ in the context of teaching excellence in contemporary universities, and reports the findings emerging from a work-in-progress study of Award Winning Teachers. It provides evidence that
Sparrow, Heather
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Tuberculosis and HIV co-infection—focus on the Asia-Pacific region
International Journal of Infectious Diseases, 2015 Tuberculosis (TB) is the leading opportunistic disease and cause of death in patients with HIV infection. In 2013 there were 1.1 million new TB/HIV co-infected cases globally, accounting for 12% of incident TB cases and 360 000 deaths.
Q.M. Trinh +5 more
doaj +1 more source