Results 71 to 80 of about 1,561,159 (250)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Comparison of photon volumetric modulated arc therapy, intensity-modulated proton therapy, and intensity-modulated carbon ion therapy for delivery of hypo-fractionated thoracic radiotherapy

Radiation Oncology, 2017
Purpose The aim of the present study was to compare the dose distribution generated from photon volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT), and intensity modulated carbon ion therapy (IMCIT) in the delivery of hypo-
Alexander Chi, Lien-Chun Lin, Sijin Wen, Haijuan Yan, Wen-Chien Hsi   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Mathematical optimization in intensity modulated radiation therapy

, 2008
The design of an intensity modulated radiotherapy treatment includes the selection of beam angles (geometry problem), the computation of an intensity map for each selected beam angle (intensity problem), and finding a sequence of configurations of a ...
Ehrgott, Matthias, Hamacher, Horst W., Shao, Lizhen, Güler, Çiğdem   +3 more
core   +4 more sources

Optically guided intensity modulated radiotherapy

Radiotherapy and Oncology, 2001
Previously, we reported on development of an optically guided system for 3D conformal intracranial radiotherapy using multiple noncoplanar fixed fields. In this paper we report on the extension of our system for stereotactic fractionated radiotherapy to include intensity modulated static ports.A 3D treatment plan with maximum beam separation is ...
Department of Human Oncology, University of Wisconsin, K4/B100 Clinical Science Center Highland Avenue, Madison, WI 53792 USA ( host institution ), Tomé, Wolfgang A., Meeks, Sanford L., McNutt, Todd R., Buatti, John M., Bova, Francis J., Friedman, William A., Mehta, Minesh   +7 more
openaire   +3 more sources

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Photonic Stepped-Frequency Intensity Modulated Comb Terahertz Radar

IEEE Journal of Microwaves
This work presents an ultra-high repetition rate (UHRR) terahertz time-domain spectroscopy (THz-TDS) system with a unique capability – it functions as a close-range pulsed radar with micrometer precision and an unambiguous range (UR) of about 3 mm.
Vladyslav Cherniak, Kevin Kolpatzeck, Jan C. Balzer   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Intensity modulated radiotherapy for elderly bladder cancer patients

Radiation Oncology, 2011
Background To review our experience and evaluate treatment planning using intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) for the treatment of elderly patients with bladder cancer. Methods From November 2006 through November 2009, we
Chong Ngot-Swan, Wu Le-Jung, Hsiao Chi-Huang, Chang Hsiao-Chun, Lai Siu-Kai, Chan Pei-Hui, Chung Shiu-Dong, Hsieh Chen-Hsi, Chen Yu-Jen, Wang Li-Ying, Hsieh Yen-Ping, Shueng Pei-Wei   +11 more
doaj   +1 more source

Rationale and development of image-guided intensity-modulated radiotherapy post-prostatectomy: the present standard of care?

, 2015
Julia R Murray,1,2 Helen A McNair,2 David P Dearnaley1,2 1Academic Urology Unit, Institute of Cancer Research, London, 2Department of Radiotherapy, The Royal Marsden NHS Foundation Trust, Sutton, UK Abstract: The indications for post-prostatectomy ...
Murray JR, McNair HA, Dearnaley DP
core