Results 81 to 90 of about 1,561,159 (250)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Intensity modulated radiation therapy for breast cancer: current perspectives
, 2017 Milly Buwenge,1 Silvia Cammelli,1 Ilario Ammendolia,1 Giorgio Tolento,1 Alice Zamagni,1 Alessandra Arcelli,2 Gabriella Macchia,3 Francesco Deodato,3 Savino Cilla,4 Alessio G Morganti1 1Department of Experimental, Diagnostic and Specialty Medicine –
Buwenge M +9 more
core
, 2017 Purpose: To report outcomes of the rare disease of squamous cell carcinoma (SCC) of the external auditory canal (EAC) and middle ear treated with surgery and postoperative intensity-modulated radiotherapy (IMRT).
陳雅芳;陳婉瑜;許權振;林凱南;郭頌鑫;成佳憲;洪瑞隆;陳育瑄;王成平;蔡巧琳;柯政郁;婁培人 +1 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Radiation Oncology, 2012 Background To compare 3 Dimensional Conformal radiotherapy (3D-CRT) with Intensity Modulated Radiotherapy (IMRT) with Volumetric-Modulated Arc Therapy (VMAT) for bladder cancer.
Foroudi Farshad +9 more
doaj +1 more source
Modulated Raman spectroscopy for enhanced cancer diagnosis at the cellular level [PDF]
, 2015 We thank the UK and Engineering and Physical Sciences Research Council through grant number EP/J01771X/1.Date of Acceptance: 24/05/2015Raman spectroscopy is emerging as a promising and novel biophotonics tool for non-invasive, real-time diagnosis of ...
De Luca, Anna Chiara +6 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Dosimetric Properties of Detectors for Quality Control of Intensity Modulated Radiotherapy
Intensity Modulated Radiotherapy (IMRT) is extensively used for cancer patients treatment in modern Radiotherapy Clinics. Patient-related Quality Control (QC) is essential part of IMRT clinical implementation, as fluencies of Intensity Modulated (IM ...
Popovs, Sergejs +3 more
core +1 more source
Dosimetric advantage of volumetric modulated arc therapy in the treatment of intraocular cancer
Radiation Oncology, 2017 Objective The purpose of this study is to investigate the dosimetric advantages of volumetric modulated arc therapy (VMAT) in the treatment of intraocular cancer by comparing it directly with three-dimensional conformal radiotherapy (CRT) and intensity ...
Zhenxiang Deng +7 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source